(S)-5-(4-Chloro-phenyl)-2-cyano-2-methyl-5-oxo-pentanoic acid isopropyl ester

Base Information

• Chemical Name: (S)-5-(4-Chloro-phenyl)-2-cyano-2-methyl-5-oxo-pentanoic acid isopropyl ester
• CAS No.: 143619-31-2
• Molecular Formula: C₁₆H₁₈ClNO₃
• Molecular Weight: 307.777
• Mol file: 143619-31-2.mol

Synonyms:(S)-5-(4-Chloro-phenyl)-2-cyano-2-methyl-5-oxo-pentanoic acid isopropyl ester

Chemical Property of (S)-5-(4-Chloro-phenyl)-2-cyano-2-methyl-5-oxo-pentanoic acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-5-(4-Chloro-phenyl)-2-cyano-2-methyl-5-oxo-pentanoic acid isopropyl ester

There total 4 articles about (S)-5-(4-Chloro-phenyl)-2-cyano-2-methyl-5-oxo-pentanoic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isopropyl 2-cyanopropanoate (30378-24-6) + p-chlorophenyl vinyl ketone (7448-87-5) → (S)-5-(4-Chloro-phenyl)-2-cyano-2-methyl-5-oxo-pentanoic acid isopropyl ester (143619-31-2) + (R)-5-(4-Chloro-phenyl)-2-cyano-2-methyl-5-oxo-pentanoic acid isopropyl ester (143619-31-2)

Guidance literature:

With carbonylhydridetris(triphenylphosphine)rhodium(I); 2,2''-bis<1-(diphenylphosphino)ethyl>-1,1''biferrocene ((S,S)-(R,R)-TRAP); In benzene; at 3 ℃; for 0.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00047a053

Reference yield:

isopropyl 2-cyanopropanoate (30378-24-6) + p-chlorophenyl vinyl ketone (7448-87-5) → (S)-5-(4-Chloro-phenyl)-2-cyano-2-methyl-5-oxo-pentanoic acid isopropyl ester (143619-31-2) + (R)-5-(4-Chloro-phenyl)-2-cyano-2-methyl-5-oxo-pentanoic acid isopropyl ester (143619-31-2)

Guidance literature:

With carbonylhydridetris(triphenylphosphine)rhodium(I); 2,2''-bis<1-(diphenylphosphino)ethyl>-1,1''biferrocene ((S,S)-(R,R)-TRAP); In benzene; at 3 ℃; for 0.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00047a053

Reference yield:

isopropyl 2-cyanopropanoate (30378-24-6) + p-chlorophenyl vinyl ketone (7448-87-5) → (R)-5-(4-Chloro-phenyl)-2-cyano-2-methyl-5-oxo-pentanoic acid isopropyl ester (143619-31-2)

Guidance literature:

With (S,S)-(R,R)-PhTRAP; (R,R)-CHIRALPHOS ; In benzene; at 3 ℃; for 4.5h; Yield given;

DOI:10.1016/S0040-4020(01)89377-7

upstream raw materials:

isopropyl 2-cyanopropanoate

p-chlorophenyl vinyl ketone