7448-87-5

Basic information

• Product Name: 2-Propen-1-one, 1-(4-chlorophenyl)-
• CAS NO: 7448-87-5
• Molecular Formula: C9H7ClO
• Molecular Weight: 166.607
• Mol File: 7448-87-5.mol
• Article Data: 50

Chemical Properties

• Melting Point: 172 °C
• Boiling Point: 81-83 °C(Press: 0.04 Torr)
• Density: 1.188 g/cm3
• CAS DataBase Reference: 2-Propen-1-one, 1-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(4-chlorophenyl)-(7448-87-5)
• EPA Substance Registry System: 2-Propen-1-one, 1-(4-chlorophenyl)-(7448-87-5)

Safety Data

• Hazardous Substances Data: 7448-87-5(Hazardous Substances Data)

Upstream product

• 3946-29-0 3,4'-Dichloropropiophenone 
• 51-80-9 bis-(dimethylamino)methane 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 
• 50-00-0 formaldehyd 
• 1777-56-6 4-chlorobenzoylmethylenetriphenylphosphorane 
• 2689-81-8 (4-chlorophenacyl)triphenylphosphonium bromide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 201230-82-2 carbon monoxide 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 122-01-0 4-chloro-benzoyl chloride 
• 58824-54-7 p-chlorophenylvinylcarbinol 
• 104-88-1 4-chlorobenzaldehyde 
• 1474048-86-6 1-(4-chlorophenyl)-3-(phenylselanyl)propan-1-one 
• 108-90-7 chlorobenzene 

Downstream Products

• 75910-29-1 1-(4-chlorophenyl)-3-tosylpropan-1-one 
• 1190719-54-0 1-(4-chlorophenyl)-2-(9-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-4-yl)ethanone 
• 120312-68-7 1-(4'-chlorophenyl)-4-(4''-methylphenyl)-butane-1,4-dione 
• 1260083-24-6 (E)-1-(4-chlorophenyl)-6-(3-methyl-1H-indol-2-yl)hex-2-en-1-one 
• 1256284-91-9 1-(4-chlorophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone 
• 1307917-13-0 1-(4-chloro-phenyl)-5-methyl-4-[1-(4-tosyl)-pyrrolidin-2-yl]-hex-4-en-1-one 
• 1384176-79-7 C₁₄H₁₅ClO₆ 
• 1384176-88-8 methyl 7-(4-chlorophenyl)-2,3,7-trioxoheptanoate 
• 1384176-71-9 methyl 7-(4-chlorophenyl)-2-diazo-3,7-dioxoheptanoate 
• 1339700-52-5 1-(4'-chlorophenyl)-4,4,4-trifluoro-1-butanone 
• 1529771-22-9 4-chloro-1-(4-chlorophenyl)-4,4-difluorobutan-1-one 
• 1529771-32-1 4-bromo-1-(4-chlorophenyl)-4,4-difluorobutan-1-one 
• 1616861-88-1 2-(2-acetyl-1-methyl-2,3-dihydro-1H-indazol-3-yl)-1-(4-chlorophenyl)-ethanone 

Relevant articles and documents

Copper-catalyzed direct sulfenoamination of saturated ketones via in situ formed enaminones

A sequential and efficient protocol for the synthesis of α-thiolated enaminones has been developed using copper-TEMPO systems. This reaction features a broad substrate scope to afford the desired product in good to excellent yields with high stereoselectivity. A preliminary mechanistic study suggests that the in situ formed enaminone acts as the key intermediate.

Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease

The protozoan parasite Trypanosoma cruzi is the causative agent of Chagas disease, the most important parasitic infection in Latin America. The only treatments currently available are nitro-derivative drugs that are characterised by high toxicity and limited efficacy. Therefore, there is an urgent need for more effective, less toxic therapeutic agents. We have previously identified the potential for Mannich base derivatives as novel inhibitors of this parasite. To further explore this family of compounds, we synthesised a panel of 69 new analogues, based on multi-parametric structure-activity relationships, which allowed optimization of both anti-parasitic activity, physicochemical parameters and ADME properties. Additionally, we optimized our in vitro screening approaches against all three developmental forms of the parasite, allowing us to discard the least effective and trypanostatic derivatives at an early stage. We ultimately identified derivative 3c, which demonstrated excellent trypanocidal properties, and a synergistic mode of action against trypomastigotes in combination with the reference drug benznidazole. Both its druggability and low-cost production make this derivative a promising candidate for the preclinical, in vivo assays of the Chagas disease drug-discovery pipeline.

PROCESS FOR THE DIRECT ALPHA-METHYLENATION OF KETONES

The invention relates to a process for preparing an α-methylene ketone comprising the step of reacting a ketone with formaldehyde in the presence of a catalyst which is an organic compound comprising at least one acid function or the corresponding salt, ester or amide thereof and at least one amine function or the corresponding ammonium salt, or a zwitterion thereof.