1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-1-piperidinecarboxylate
CAS No.:1095274-70-6
Molecular Formula:C₁₉H₂₆ClNO₄
Molecular Weight:367.873
Hs Code.:

Synonyms:1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-1-piperidinecarboxylate

Chemical Property:

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Technology Process of 1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-1-piperidinecarboxylate

There total 6 articles about 1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095274-69-3
1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1095274-70-6
1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-1-piperidinecarboxylate

Guidance literature:: With hydrogen; platinum(IV) oxide; In tetrahydrofuran; at 20 ℃; for 168h;

Reference yield:

: 1095274-55-7
3-bromo-5-chlorobenzoic acid ethyl ester

: 1095274-70-6
1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.67 h / 100 - 120 °C / Microwave irradition

2: hydrogen / platinum(IV) oxide / tetrahydrofuran / 168 h / 20 °C

With hydrogen; sodium carbonate; platinum(IV) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 42860-02-6
3‐bromo‐5‐chlorobenzoic acid

: 1095274-70-6
1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 1 h / Heating / reflux

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.67 h / 100 - 120 °C / Microwave irradition

3: hydrogen / platinum(IV) oxide / tetrahydrofuran / 168 h / 20 °C

With sulfuric acid; hydrogen; sodium carbonate; platinum(IV) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water;