4-{4-[1-Amino-2-(2-fluoro-phenyl)-ethyl]-phenyl}-butyric acid methyl ester

Base Information

Chemical Name:4-{4-[1-Amino-2-(2-fluoro-phenyl)-ethyl]-phenyl}-butyric acid methyl ester
CAS No.:162941-59-5
Molecular Formula:C₁₉H₂₂FNO₂
Molecular Weight:315.388
Hs Code.:

Synonyms:4-{4-[1-Amino-2-(2-fluoro-phenyl)-ethyl]-phenyl}-butyric acid methyl ester

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Chemical Property of 4-{4-[1-Amino-2-(2-fluoro-phenyl)-ethyl]-phenyl}-butyric acid methyl ester

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Technology Process of 4-{4-[1-Amino-2-(2-fluoro-phenyl)-ethyl]-phenyl}-butyric acid methyl ester

There total 6 articles about 4-{4-[1-Amino-2-(2-fluoro-phenyl)-ethyl]-phenyl}-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 162977-05-1
4-{4-[1-Azido-2-(2-fluoro-phenyl)-ethyl]-phenyl}-butyric acid methyl ester

: 162941-59-5
4-{4-[1-Amino-2-(2-fluoro-phenyl)-ethyl]-phenyl}-butyric acid methyl ester

Guidance literature:: With hydrogen; platinum(IV) oxide; In methanol; under 760 Torr; Ambient temperature;
DOI:10.1248/cpb.44.765

Reference yield:

: 2046-17-5
methyl 3-(benzyl)propanoate

: 162941-59-5
4-{4-[1-Amino-2-(2-fluoro-phenyl)-ethyl]-phenyl}-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: AlCl₃ / CS₂ / Heating

2: NaBH₄ / methanol / Ambient temperature

3: SOCl₂ / benzene / Heating

4: NaN₃ / dimethylformamide / 50 - 60 °C

5: 81 percent / H₂ / PtO₂ / methanol / 760 Torr / Ambient temperature

With sodium tetrahydroborate; aluminium trichloride; thionyl chloride; sodium azide; hydrogen; platinum(IV) oxide; In methanol; carbon disulfide; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.44.765

Reference yield:

: 162939-90-4
4-{4-[2-(2-Fluoro-phenyl)-acetyl]-phenyl}-butyric acid methyl ester

: 162941-59-5
4-{4-[1-Amino-2-(2-fluoro-phenyl)-ethyl]-phenyl}-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄ / methanol / Ambient temperature

2: SOCl₂ / benzene / Heating

3: NaN₃ / dimethylformamide / 50 - 60 °C

4: 81 percent / H₂ / PtO₂ / methanol / 760 Torr / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; sodium azide; hydrogen; platinum(IV) oxide; In methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.44.765