methyl 4-[4-[1-(4-chlorophenylsulfonylamino)-2-(2-fluorophenyl)ethyl]phenyl]butyrate

Base Information

Chemical Name:methyl 4-[4-[1-(4-chlorophenylsulfonylamino)-2-(2-fluorophenyl)ethyl]phenyl]butyrate
CAS No.:162938-86-5
Molecular Formula:C₂₅H₂₅ClFNO₄S
Molecular Weight:489.995
Hs Code.:

Synonyms:methyl 4-[4-[1-(4-chlorophenylsulfonylamino)-2-(2-fluorophenyl)ethyl]phenyl]butyrate

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Chemical Property of methyl 4-[4-[1-(4-chlorophenylsulfonylamino)-2-(2-fluorophenyl)ethyl]phenyl]butyrate

Chemical Property:

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Technology Process of methyl 4-[4-[1-(4-chlorophenylsulfonylamino)-2-(2-fluorophenyl)ethyl]phenyl]butyrate

There total 8 articles about methyl 4-[4-[1-(4-chlorophenylsulfonylamino)-2-(2-fluorophenyl)ethyl]phenyl]butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 162941-59-5
4-{4-[1-Amino-2-(2-fluoro-phenyl)-ethyl]-phenyl}-butyric acid methyl ester

: 162938-86-5
methyl 4-[4-[1-(4-chlorophenylsulfonylamino)-2-(2-fluorophenyl)ethyl]phenyl]butyrate

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1248/cpb.44.765

Reference yield:

: 2046-17-5
methyl 3-(benzyl)propanoate

: 162938-86-5
methyl 4-[4-[1-(4-chlorophenylsulfonylamino)-2-(2-fluorophenyl)ethyl]phenyl]butyrate

Guidance literature:: Multi-step reaction with 6 steps

1: AlCl₃ / CS₂ / Heating

2: NaBH₄ / methanol / Ambient temperature

3: SOCl₂ / benzene / Heating

4: NaN₃ / dimethylformamide / 50 - 60 °C

5: 81 percent / H₂ / PtO₂ / methanol / 760 Torr / Ambient temperature

6: 91 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With sodium tetrahydroborate; aluminium trichloride; thionyl chloride; sodium azide; hydrogen; triethylamine; platinum(IV) oxide; In methanol; carbon disulfide; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.44.765

Reference yield:

: 162939-90-4
4-{4-[2-(2-Fluoro-phenyl)-acetyl]-phenyl}-butyric acid methyl ester

: 162938-86-5
methyl 4-[4-[1-(4-chlorophenylsulfonylamino)-2-(2-fluorophenyl)ethyl]phenyl]butyrate

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / methanol / Ambient temperature

2: SOCl₂ / benzene / Heating

3: NaN₃ / dimethylformamide / 50 - 60 °C

4: 81 percent / H₂ / PtO₂ / methanol / 760 Torr / Ambient temperature

5: 91 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; sodium azide; hydrogen; triethylamine; platinum(IV) oxide; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.44.765