2-(4-methoxybenzyl)-8-methyl-7,8-dihydropyrazolo[3,4-b]azepin-4(2H)-one

Base Information

Chemical Name:2-(4-methoxybenzyl)-8-methyl-7,8-dihydropyrazolo[3,4-b]azepin-4(2H)-one
CAS No.:1355994-14-7
Molecular Formula:C₁₆H₁₇N₃O₂
Molecular Weight:283.33
Hs Code.:

Synonyms:2-(4-methoxybenzyl)-8-methyl-7,8-dihydropyrazolo[3,4-b]azepin-4(2H)-one

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Chemical Property of 2-(4-methoxybenzyl)-8-methyl-7,8-dihydropyrazolo[3,4-b]azepin-4(2H)-one

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Technology Process of 2-(4-methoxybenzyl)-8-methyl-7,8-dihydropyrazolo[3,4-b]azepin-4(2H)-one

There total 8 articles about 2-(4-methoxybenzyl)-8-methyl-7,8-dihydropyrazolo[3,4-b]azepin-4(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1355994-13-6
1-(3-(allyl(methyl)amino)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)prop-2-en-1-one

: 1355994-14-7
2-(4-methoxybenzyl)-8-methyl-7,8-dihydropyrazolo[3,4-b]azepin-4(2H)-one

Guidance literature:: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 1h; Inert atmosphere; Reflux;

Reference yield:

: 1105039-59-5
N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

: 1355994-14-7
2-(4-methoxybenzyl)-8-methyl-7,8-dihydropyrazolo[3,4-b]azepin-4(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

1.2: 1.08 h / -78 - 20 °C

2.1: 1-methyl-pyrrolidin-2-one / 1.5 h / 140 °C / Microwave irradiation

3.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran / 20 h / 45 °C

3.2: 2 h / 65 °C

4.1: tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

5.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 1 h / Inert atmosphere; Reflux

With sodium hydride; lithium diisopropyl amide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1355994-14-7
2-(4-methoxybenzyl)-8-methyl-7,8-dihydropyrazolo[3,4-b]azepin-4(2H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / acetonitrile / 4 h / Reflux

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 60 °C

2.2: pH 1 - 2

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

3.2: 1 h / 0 - 20 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

4.2: 1.08 h / -78 - 20 °C

5.1: 1-methyl-pyrrolidin-2-one / 1.5 h / 140 °C / Microwave irradiation

6.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran / 20 h / 45 °C

6.2: 2 h / 65 °C

7.1: tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

8.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 1 h / Inert atmosphere; Reflux

With oxalyl dichloride; water; sodium hydride; potassium carbonate; N,N-dimethyl-formamide; lithium hydroxide; lithium diisopropyl amide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;