Technology Process of 2-((R)-1,5-Dimethyl-hex-4-enyl)-4-methyl-6-phenylselanyl-cyclohex-2-enone
There total 5 articles about 2-((R)-1,5-Dimethyl-hex-4-enyl)-4-methyl-6-phenylselanyl-cyclohex-2-enone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-[(1R)-1,5-dimethylhex-4-enyl]-4-methylcyclohex-2-en-1-one;
With
N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 - 0 ℃;
for 1h;
Phenylselenyl chloride;
In
tetrahydrofuran;
at -78 ℃;
for 0.25h;
Further stages.;
DOI:10.1039/b200629b
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Mg / tetrahydrofuran / 2 h / 20 °C
1.2: 100 percent / tetrahydrofuran / 3 h / 20 °C
2.1: tetrapropylammonium perruthenate; 4 Angstroem molecular sieves; N-methylmorpholine N-oxide / CH2Cl2 / 2 h / 0 °C
3.1: 115 mg / DEA / acetonitrile / 24 h / 80 °C
4.1: 95 percent / tetrabutylammonium hydroxide; aq. KOH / tetrahydrofuran; diethyl ether / 3 h / Heating
5.1: LDA; HMPA / tetrahydrofuran / 1 h / -78 - 0 °C
5.2: 93 percent / tetrahydrofuran / 0.25 h / -78 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; tetrapropylammonium perruthennate; 4 A molecular sieve; tetra(n-butyl)ammonium hydroxide; magnesium; 4-methylmorpholine N-oxide; 2,2'-iminobis[ethanol]; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1039/b200629b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 115 mg / DEA / acetonitrile / 24 h / 80 °C
2.1: 95 percent / tetrabutylammonium hydroxide; aq. KOH / tetrahydrofuran; diethyl ether / 3 h / Heating
3.1: LDA; HMPA / tetrahydrofuran / 1 h / -78 - 0 °C
3.2: 93 percent / tetrahydrofuran / 0.25 h / -78 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; tetra(n-butyl)ammonium hydroxide; 2,2'-iminobis[ethanol]; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1039/b200629b
