2-AMINO-2-ETHYLHEXANOIC ACID

Base Information

• Chemical Name: 2-AMINO-2-ETHYLHEXANOIC ACID
• CAS No.: 114781-15-6
• Molecular Formula: C₈H₁₇NO₂
• Molecular Weight: 159.228
• Hs Code.: 2922499990
• Mol file: 114781-15-6.mol

Synonyms:2-AMINO-2-ETHYLHEXANOIC ACID

Chemical Property of 2-AMINO-2-ETHYLHEXANOIC ACID

Chemical Property:

• PSA: 63.32000
• LogP: 2.06900

Purity/Quality:

99%min ^*data from raw suppliers

2-Amino-2-ethylhexanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-2-ETHYLHEXANOIC ACID

There total 7 articles about 2-AMINO-2-ETHYLHEXANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Amino-2-ethyl-hexanoic acid (6300-78-3) → (S)-2-amino-2-ethylhexanoic acid (114781-15-6)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄ / Heating

2: 31 percent / porcine liver esterase / aq. phosphate buffer / 7.5 h / 30 °C / pH 8.0

3: NaOH / H₂O / 21 h / 20 - 50 °C

With porcine liver esterase; sodium hydroxide; sulfuric acid; In phosphate buffer; water; 1: Esterification / 2: Hydrolysis / 3: Hydrolysis;

DOI:10.1002/1522-2675(20001004)83:10<2823::AID-HLCA2823>3.0.CO;2-#

Reference yield:

heptan-3-one (106-35-4) → (S)-2-amino-2-ethylhexanoic acid (114781-15-6)

Guidance literature:

Multi-step reaction with 5 steps

1: NH₄Cl / H₂O; ethanol / 48 h / 55 - 60 °C

2: conc. HCl / 24 h / 80 °C

3: H₂SO₄ / Heating

4: 31 percent / porcine liver esterase / aq. phosphate buffer / 7.5 h / 30 °C / pH 8.0

5: NaOH / H₂O / 21 h / 20 - 50 °C

With hydrogenchloride; porcine liver esterase; sodium hydroxide; sulfuric acid; ammonium chloride; In phosphate buffer; ethanol; water; 1: Condensation / 2: Hydrolysis / 3: Esterification / 4: Hydrolysis / 5: Hydrolysis;

DOI:10.1002/1522-2675(20001004)83:10<2823::AID-HLCA2823>3.0.CO;2-#

Reference yield:

2-amino-2-ethylhexanonitrile (58577-05-2) → (S)-2-amino-2-ethylhexanoic acid (114781-15-6)

Guidance literature:

Multi-step reaction with 4 steps

1: conc. HCl / 24 h / 80 °C

2: H₂SO₄ / Heating

3: 31 percent / porcine liver esterase / aq. phosphate buffer / 7.5 h / 30 °C / pH 8.0

4: NaOH / H₂O / 21 h / 20 - 50 °C

With hydrogenchloride; porcine liver esterase; sodium hydroxide; sulfuric acid; In phosphate buffer; water; 1: Hydrolysis / 2: Esterification / 3: Hydrolysis / 4: Hydrolysis;

DOI:10.1002/1522-2675(20001004)83:10<2823::AID-HLCA2823>3.0.CO;2-#

upstream raw materials:

(3S,6S)-3-butyl-3,6-diethyl-2,5-dimethoxy-3,6-dihydropyrazine

(+/-)-ethyl 2-amino-2-ethylhexanoate

2-Amino-2-ethyl-hexanoic acid

heptan-3-one

Refernces

• 1、 Liu, Weiguo,Ray, Paul,Benezra, Steven A.. "Chemo-Enzymic Synthesis of Optically Active α,α-Disubstituted α-Amino Acids". . p. 553 - 560. Retrieved 2007/10/02.