2-(5-cyclohexyl-3-methyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)-N-cyclopropylacetamide

Base Information

Chemical Name:2-(5-cyclohexyl-3-methyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)-N-cyclopropylacetamide
CAS No.:1384248-82-1
Molecular Formula:C₂₀H₂₆N₄O₃
Molecular Weight:370.451
Hs Code.:

Synonyms:2-(5-cyclohexyl-3-methyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)-N-cyclopropylacetamide

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Chemical Property of 2-(5-cyclohexyl-3-methyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)-N-cyclopropylacetamide

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Technology Process of 2-(5-cyclohexyl-3-methyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)-N-cyclopropylacetamide

There total 6 articles about 2-(5-cyclohexyl-3-methyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)-N-cyclopropylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1384248-65-0
methyl 2-(5-cyclohexyl-3-methyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)acetate

: 765-30-0
Cyclopropylamine

: 1384248-82-1
2-(5-cyclohexyl-3-methyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)-N-cyclopropylacetamide

Guidance literature:: at 150 ℃; for 0.5h; Microwave irradiation; Neat (no solvent);
DOI:10.1016/j.tetlet.2012.05.025

Reference yield:

: 74628-31-2
N-1-cyclohexylbenzene-1,2-diamine

: 1384248-82-1
2-(5-cyclohexyl-3-methyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)-N-cyclopropylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 65 °C

2.1: 2,4-dichlorophenoxyacetic acid dimethylamine / 0.5 h / 150 °C / Microwave irradiation

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

3.2: 16 h

4.1: 0.5 h / 150 °C / Microwave irradiation; Neat (no solvent)

With sodium hydride; potassium carbonate; In 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetlet.2012.05.025

Reference yield:

: 6373-71-3
N-cyclohexyl-2-nitroaniline

: 1384248-82-1
2-(5-cyclohexyl-3-methyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)-N-cyclopropylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 65 °C

3.1: 2,4-dichlorophenoxyacetic acid dimethylamine / 0.5 h / 150 °C / Microwave irradiation

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

4.2: 16 h

5.1: 0.5 h / 150 °C / Microwave irradiation; Neat (no solvent)

With palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; In ethanol; 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetlet.2012.05.025