4-benzyl 1-tert-butyl (2S)-2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

Base Information

Chemical Name:4-benzyl 1-tert-butyl (2S)-2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate
CAS No.:1450620-15-1
Molecular Formula:C₂₀H₂₆N₂O₄
Molecular Weight:358.437
Hs Code.:

Synonyms:4-benzyl 1-tert-butyl (2S)-2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

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Chemical Property of 4-benzyl 1-tert-butyl (2S)-2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

Chemical Property:

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Technology Process of 4-benzyl 1-tert-butyl (2S)-2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

There total 8 articles about 4-benzyl 1-tert-butyl (2S)-2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450620-14-0
4-benzyl 1-tert-butyl 2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

: 1450620-15-1
4-benzyl 1-tert-butyl (2S)-2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

: 4-benzyl 1-tert-butyl (2R)-2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

Guidance literature:: With Chiralpak ADH column; In ethanol; Resolution of racemate;

Reference yield:

: 1228675-25-9
2-oxopiperazine-1,4-dicarboxylic acid 1-tert-butyl ester 4-benzyl ester

: 1450620-15-1
4-benzyl 1-tert-butyl (2S)-2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

: 4-benzyl 1-tert-butyl (2R)-2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 2 h / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 0.25 h / -10 - 20 °C

2.2: 2.17 h

3.1: triethylamine; dmap / dichloromethane / 0.5 h / 20 °C

4.1: Chiralpak^? ADH column / ethanol / Resolution of racemate

With dmap; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 78818-15-2
4-benzyloxycarbonylpiperazin-2-one

: 1450620-15-1
4-benzyl 1-tert-butyl (2S)-2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

: 4-benzyl 1-tert-butyl (2R)-2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; dmap / dichloromethane / 1 h / 20 °C

2.1: tetrahydrofuran / 2 h / 0 °C

3.1: trifluoroacetic acid / dichloromethane / 0.25 h / -10 - 20 °C

3.2: 2.17 h

4.1: triethylamine; dmap / dichloromethane / 0.5 h / 20 °C

5.1: Chiralpak^? ADH column / ethanol / Resolution of racemate

With dmap; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane;