tert-butyl (5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Base Information

Chemical Name:tert-butyl (5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate
CAS No.:1572928-14-3
Molecular Formula:C₂₄H₃₀N₄O₅S₂
Molecular Weight:518.658
Hs Code.:

Synonyms:tert-butyl (5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

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Chemical Property of tert-butyl (5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

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Technology Process of tert-butyl (5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

There total 14 articles about tert-butyl (5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450620-16-2
tert-butyl (5-(chlorosulfonyl)-2-pyridinyl)carbamate

: 1572928-13-2
⁽²⁵⁾-1-(4-(methylsulfinyl)phenyl)-2-(1-propyn-1-yl)piperazine

: 1572928-14-3
tert-butyl (5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 104-95-0
(4-bromophenyl)thioanisole

: 1572928-14-3
tert-butyl (5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: dihydrogen peroxide; acetic acid / water / 0 - 20 °C

2: 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 18 h / 20 - 100 °C / Inert atmosphere

3: sulfuric acid / chloroform / 1 h / 0 - 20 °C

4: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; dihydrogen peroxide; acetic acid; triethylamine; sodium t-butanolate; 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine; In 1,4-dioxane; dichloromethane; chloroform; water;

Reference yield:

: 934-71-4
1-bromo-4-(methylsulfinyl)benzene

: 1572928-14-3
tert-butyl (5-(((3S)-4-(4-(methylsulfinyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 18 h / 20 - 100 °C / Inert atmosphere

2: sulfuric acid / chloroform / 1 h / 0 - 20 °C

3: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; triethylamine; sodium t-butanolate; 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine; In 1,4-dioxane; dichloromethane; chloroform;