trans-3-(Benzyloxymethyl)cyclobutyl4-nitrobenzoate

Base Information

Chemical Name:trans-3-(Benzyloxymethyl)cyclobutyl4-nitrobenzoate
CAS No.:172324-70-8
Molecular Formula:C₁₉H₁₉NO₅
Molecular Weight:341.364
Hs Code.:
DSSTox Substance ID:DTXSID501156154

Synonyms:172324-70-8;trans-3-(Benzyloxymethyl)cyclobutyl4-nitrobenzoate;Cyclobutanol, 3-[(phenylmethoxy)methyl]-, 1-(4-nitrobenzoate), trans-;[3-(phenylmethoxymethyl)cyclobutyl] 4-nitrobenzoate;(1r,3r)-3-((Benzyloxy)methyl)cyclobutyl 4-nitrobenzoate;starbld0000652;SCHEMBL3953745;SCHEMBL3953747;ZUMRTMZYWBVEBP-RZDIXWSQSA-N;DTXSID501156154;AKOS037651038;CS-15752;CS-0042471;D72219;Trans-3-[(benzyloxy)methyl]cyclobutyl 4-nitrobenzoate

Suppliers and Price of trans-3-(Benzyloxymethyl)cyclobutyl4-nitrobenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of trans-3-(Benzyloxymethyl)cyclobutyl4-nitrobenzoate

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:341.12632271
Heavy Atom Count:25
Complexity:443

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(CC1OC(=O)C2=CC=C(C=C2)[N+](=O)[O-])COCC3=CC=CC=C3

Technology Process of trans-3-(Benzyloxymethyl)cyclobutyl4-nitrobenzoate

There total 6 articles about trans-3-(Benzyloxymethyl)cyclobutyl4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 172324-68-4
(1s,3s)-3-((benzyloxy)methyl)cyclobutanol

: 62-23-7
4-nitro-benzoic acid

: 172324-70-8
(1r,3r)-3-((benzyloxy)methyl)cyclobutyl 4-nitrobenzoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 6h; Inert atmosphere;

Reference yield:

: cis 3-((benzyloxy)methyl)-1-cyclobutanol

: 62-23-7
4-nitro-benzoic acid

: 172324-70-8
(1r,3r)-3-((benzyloxy)methyl)cyclobutyl 4-nitrobenzoate

: cis-3-(benzyloxymethyl)cyclobutyl 4-nitrobenzoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

Reference yield:

: 172324-67-3
3-benzyloxymethyl-cyclobutanone

: 172324-70-8
(1r,3r)-3-((benzyloxy)methyl)cyclobutyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / L-Selectride / tetrahydrofuran / -78 °C

2: 50 percent / Ph₃P; DEAD / tetrahydrofuran / 20 °C

With L-Selectride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2007.03.094