CIS-3-BENZYLOXYMETHYLCYCLOBUTANOL

Base Information

• Chemical Name: CIS-3-BENZYLOXYMETHYLCYCLOBUTANOL
• CAS No.: 172324-68-4
• Molecular Formula: C12H16 O2
• Molecular Weight: 192.258
• Mol file: 172324-68-4.mol

Synonyms:cis-3-[(Benzyloxy)methyl]-1-cyclobutanol;cis-3-[(Benzyloxy)methyl]cyclobutanol

Chemical Property of CIS-3-BENZYLOXYMETHYLCYCLOBUTANOL

Chemical Property:

• PSA: 29.46000
• LogP: 1.97410

Purity/Quality:

99% ^*data from raw suppliers

cis-3-Benzyloxymethylcyclobutanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: cis-3-(Benzyloxymethyl)cyclobutanol is generally used as a intermediate in chemical research.

Technology Process of CIS-3-BENZYLOXYMETHYLCYCLOBUTANOL

There total 6 articles about CIS-3-BENZYLOXYMETHYLCYCLOBUTANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(1r,3r)-3-((benzyloxy)methyl)cyclobutyl 4-nitrobenzoate (172324-70-8) → (1s,3s)-3-((benzyloxy)methyl)cyclobutanol (172324-68-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 16h;

Reference yield: 92.0%

3-benzyloxymethyl-cyclobutanone (172324-67-3) → (1s,3s)-3-((benzyloxy)methyl)cyclobutanol (172324-68-4)

Guidance literature:

With L-Selectride; In tetrahydrofuran; at -70 - 20 ℃; for 16h;

Reference yield: 91.0%

3-benzyloxymethyl-cyclobutanone (172324-67-3) → (1r,3r)-3-((benzyloxy)methyl)cyclobutanol (172324-65-1) + (1s,3s)-3-((benzyloxy)methyl)cyclobutanol (172324-68-4)

Guidance literature:

With L-Selectride; In tetrahydrofuran; at -70 - 25 ℃; for 18h; Inert atmosphere;

upstream raw materials:

3-benzyloxymethyl-cyclobutanone

benzyl allyl ether

3-(benzyloxymethyl)-2,2-dichlorocyclobutanone

benzyl alcohol

Downstream raw materials:

(1r,3r)-3-((benzyloxy)methyl)cyclobutyl 4-nitrobenzoate

(cis-3-(benzyloxymethyl)cyclobutoxy)(tert-butyl)dimethylsilane

(((cis-3-methoxycyclobutyl)methoxy)methyl)benzene

cis-3-[(benzyloxy)methyl]cyclobutyl-p-toluenesulphonate

Refernces

• 1、 -. "IRAK DEGRADERS AND USES THEREOF". Paragraph 00920; 001251-001253; 002232. . Retrieved 2021/01/23.
• 2、 -. "USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN". Page/Page column 78. . Retrieved 2008/06/13.