(2R,3E,5S,6S,7S,8R)-1,9-di(tert-butyldiphenylsilyloxy)-6-hydroxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol

Base Information

• Chemical Name: (2R,3E,5S,6S,7S,8R)-1,9-di(tert-butyldiphenylsilyloxy)-6-hydroxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol
• CAS No.: 240821-12-9
• Molecular Formula: C₅₄H₇₂O₇Si₂
• Molecular Weight: 889.332

Synonyms:(2R,3E,5S,6S,7S,8R)-1,9-di(tert-butyldiphenylsilyloxy)-6-hydroxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol

Chemical Property of (2R,3E,5S,6S,7S,8R)-1,9-di(tert-butyldiphenylsilyloxy)-6-hydroxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3E,5S,6S,7S,8R)-1,9-di(tert-butyldiphenylsilyloxy)-6-hydroxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol

There total 26 articles about (2R,3E,5S,6S,7S,8R)-1,9-di(tert-butyldiphenylsilyloxy)-6-hydroxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2R,3E,6S,7S,8R)-1,9-di(tert-butyldiphenylsilyloxy)-6-hydroxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-one (240821-10-7) → (2R,3E,5S,6S,7S,8R)-1,9-di(tert-butyldiphenylsilyloxy)-6-hydroxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol (240821-12-9)

Guidance literature:

With zinc(II) tetrahydroborate; In diethyl ether; at 0 ℃;

DOI:10.1055/s-1999-2730

Reference yield: 70.0%

(2R,3E,5S,6S,7S,8R)-6-(tert-butyldimethylsilyloxymethyl)-1,9-di(tert-butyldiphenylsilyloxy)-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol (252006-18-1) → (2R,3E,5S,6S,7S,8R)-1,9-di(tert-butyldiphenylsilyloxy)-6-hydroxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol (240821-12-9)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; at 50 ℃; for 2h;

DOI:10.1248/cpb.47.1288

Reference yield: 26.0%

(2R,3E,6S,7S,8R)-6-(tert-butyldimethylsilyloxymethyl)-1,9-di(tert-butyldiphenylsilyloxy)-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-one (240821-06-1) → (2R,3E,5S,6S,7S,8R)-1,9-di(tert-butyldiphenylsilyloxy)-6-hydroxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol (240821-12-9) + (2R,3E,5S,6S,7S,8R)-6-(tert-butyldimethylsilyloxymethyl)-1,9-di(tert-butyldiphenylsilyloxy)-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol (252006-18-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -50 - -30 ℃; for 0.333333h;

DOI:10.1248/cpb.47.1288

upstream raw materials:

(2R,3E,6S,7S,8R)-1,9-di(tert-butyldiphenylsilyloxy)-6-hydroxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-one

(2R,3E,6S,7S,8R)-6-(tert-butyldimethylsilyloxymethyl)-1,9-di(tert-butyldiphenylsilyloxy)-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-one

(2R,3E,5S,6S,7S,8R)-6-(tert-butyldimethylsilyloxymethyl)-1,9-di(tert-butyldiphenylsilyloxy)-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol

(2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropanal

Downstream raw materials:

2,2-Dimethyl-propionic acid (E)-(2R,3S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2-[(1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-3-hydroxy-4,6-dimethyl-hept-4-enyl ester

(2Z,4S,5E,7S,8S,9S,10R)-9,11-[(S)-3,4-dimethoxybenzylidenedioxy]-8-hydroxymethyl-4,6,10-trimethyl-2,5-undecadien-7-ol

(2R,3E,5S,6S,7S,8R)-5-acetoxy-6-acetoxymethyl-7,9-[(S)-3,4-dimethoxybenzylidenedioxy]-2,4,8-trimethyl-3-nonenal

Acetic acid (E)-(1S,4R)-1-{(S)-2-acetoxy-1-[(2S,4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-ethyl}-5-hydroxy-2,4-dimethyl-pent-2-enyl ester

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