N-((3-chlorophenyl)(4-(1-tert-butoxycarbonylpiperazin-4-ylmethyl)phenyl)methyl)-7-chloro-4-aminoquinoline

Base Information

• Chemical Name: N-((3-chlorophenyl)(4-(1-tert-butoxycarbonylpiperazin-4-ylmethyl)phenyl)methyl)-7-chloro-4-aminoquinoline
• CAS No.: 1392422-16-0
• Molecular Formula: C₃₂H₃₄Cl₂N₄O₂
• Molecular Weight: 577.554

Synonyms:N-((3-chlorophenyl)(4-(1-tert-butoxycarbonylpiperazin-4-ylmethyl)phenyl)methyl)-7-chloro-4-aminoquinoline

Chemical Property of N-((3-chlorophenyl)(4-(1-tert-butoxycarbonylpiperazin-4-ylmethyl)phenyl)methyl)-7-chloro-4-aminoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((3-chlorophenyl)(4-(1-tert-butoxycarbonylpiperazin-4-ylmethyl)phenyl)methyl)-7-chloro-4-aminoquinoline

There total 3 articles about N-((3-chlorophenyl)(4-(1-tert-butoxycarbonylpiperazin-4-ylmethyl)phenyl)methyl)-7-chloro-4-aminoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

4-amino-7-chloroquinoline (1198-40-9) + (3-chlorophenyl){4-[(N-tert-butoxycarbonylpiperazin-4-yl)methyl]phenyl}methanol (949934-32-1) → N-((3-chlorophenyl)(4-(1-tert-butoxycarbonylpiperazin-4-ylmethyl)phenyl)methyl)-7-chloro-4-aminoquinoline (1392422-16-0)

Guidance literature:

(3-chlorophenyl){4-[(N-tert-butoxycarbonylpiperazin-4-yl)methyl]phenyl}methanol; With thionyl chloride; In dichloromethane; at 0 - 45 ℃; for 4.33h;

4-amino-7-chloroquinoline; With triethylamine; In acetonitrile; at 0 - 80 ℃; for 6h;

DOI:10.1021/jm300802s

Reference yield:

(4-bromomethyl-phenyl)(3-chloro-phenyl)methanone (945657-22-7) → N-((3-chlorophenyl)(4-(1-tert-butoxycarbonylpiperazin-4-ylmethyl)phenyl)methyl)-7-chloro-4-aminoquinoline (1392422-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / acetonitrile / 1 h / 0 °C

2.1: sodium tetrahydroborate / ethanol / 1 h / 0 °C

3.1: thionyl chloride / dichloromethane / 4.33 h / 0 - 45 °C

3.2: 6 h / 0 - 80 °C

With sodium tetrahydroborate; thionyl chloride; triethylamine; In ethanol; dichloromethane; acetonitrile;

DOI:10.1021/jm300802s

Reference yield:

1-t-Butoxycarbonylpiperazine (57260-71-6) → N-((3-chlorophenyl)(4-(1-tert-butoxycarbonylpiperazin-4-ylmethyl)phenyl)methyl)-7-chloro-4-aminoquinoline (1392422-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / acetonitrile / 1 h / 0 °C

2.1: sodium tetrahydroborate / ethanol / 1 h / 0 °C

3.1: thionyl chloride / dichloromethane / 4.33 h / 0 - 45 °C

3.2: 6 h / 0 - 80 °C

With sodium tetrahydroborate; thionyl chloride; triethylamine; In ethanol; dichloromethane; acetonitrile;

DOI:10.1021/jm300802s

upstream raw materials:

(4-bromomethyl-phenyl)(3-chloro-phenyl)methanone

4-amino-7-chloroquinoline

(3-chlorophenyl){4-[(N-tert-butoxycarbonylpiperazin-4-yl)methyl]phenyl}methanol

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

C₂₇H₂₆Cl₂N₄

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1392422-16-0 N-((3-chlorophenyl)(4-(1-tert-butoxycarbonylpiperazin-4-ylmethyl)phenyl)methyl)-7-chloro-4-aminoquinoline

Send

Send

Metric Ton KG G Pound L ML

Send

Send