[L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-methyl-5-phenyl-2-pentenoic acid

Base Information

Chemical Name:[L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-methyl-5-phenyl-2-pentenoic acid
CAS No.:356788-71-1
Molecular Formula:C₁₇H₂₃NO₄
Molecular Weight:305.374
Hs Code.:

Synonyms:[L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-methyl-5-phenyl-2-pentenoic acid

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Chemical Property of [L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-methyl-5-phenyl-2-pentenoic acid

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Technology Process of [L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-methyl-5-phenyl-2-pentenoic acid

There total 7 articles about [L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-methyl-5-phenyl-2-pentenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 244033-72-5
(4S)-4-N-tert-butoxycarbonylamino-5-phenyl-2-methyl-2-trans-pentenoic acid, ethyl ester

: 356788-71-1
[L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-methyl-5-phenyl-2-pentenoic acid

Guidance literature:: (4S)-4-N-tert-butoxycarbonylamino-5-phenyl-2-methyl-2-trans-pentenoic acid, ethyl ester; With sodium hydroxide; In 1,4-dioxane; at 80 ℃; for 2h;

With hydrogenchloride; In water; pH=2;
DOI:10.1002/ejoc.200900999

Reference yield:

: 72155-45-4
Boc-L-phenylalaninal

: 356788-71-1
[L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-methyl-5-phenyl-2-pentenoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 0.25 g / CH₂Cl₂ / 14 h / 0 - 20 °C

2: aq. NaOH / ethanol / 12 h / 20 °C

With sodium hydroxide; In ethanol; dichloromethane; 1: Wiitig olefination;
DOI:10.1021/ol048252i

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 356788-71-1
[L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-methyl-5-phenyl-2-pentenoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: NaBr; TEMPO; NaOCl / H₂O; toluene; ethyl acetate / 4 h / 0 °C

2: 0.25 g / CH₂Cl₂ / 14 h / 0 - 20 °C

3: aq. NaOH / ethanol / 12 h / 20 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydroxide; sodium hypochlorite; sodium bromide; In ethanol; dichloromethane; water; ethyl acetate; toluene; 2: Wiitig olefination;
DOI:10.1021/ol048252i