6-(2-chloro-6-fluorophenyl)-8-methyl-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one

Base Information

Chemical Name:6-(2-chloro-6-fluorophenyl)-8-methyl-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one
CAS No.:1452231-44-5
Molecular Formula:C₁₅H₁₁ClFN₃OS
Molecular Weight:335.789
Hs Code.:

Synonyms:6-(2-chloro-6-fluorophenyl)-8-methyl-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one

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Chemical Property of 6-(2-chloro-6-fluorophenyl)-8-methyl-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one

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Technology Process of 6-(2-chloro-6-fluorophenyl)-8-methyl-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one

There total 4 articles about 6-(2-chloro-6-fluorophenyl)-8-methyl-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1452231-43-4
N-(2-chloro-6-fluorophenyl)-4-ethyl-2-(methylthio)pyrimidine-5-carboxamide

: 3724-43-4,149409-22-3
Vilsmeier reagent

: 1452231-44-5
6-(2-chloro-6-fluorophenyl)-8-methyl-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: In ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 4949-44-4
ethyl propanoylacetate

: 1452231-44-5
6-(2-chloro-6-fluorophenyl)-8-methyl-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 0.17 h / 80 °C

1.2: 16 h / 110 °C

2.1: lithium hydroxide / water; tetrahydrofuran; methanol / 3 h / 20 °C

3.1: N,N-dimethyl-formamide; thionyl chloride / 1,4-dioxane / 1 h / 20 °C

3.2: 16 h / 100 °C

4.1: ethyl acetate; N,N-dimethyl-formamide / 16 h / 20 °C

With thionyl chloride; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: ethyl 4-ethyl-2-(methylthio)pyrimidine-5-carboxylate

: 1452231-44-5
6-(2-chloro-6-fluorophenyl)-8-methyl-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / water; tetrahydrofuran; methanol / 3 h / 20 °C

2.1: N,N-dimethyl-formamide; thionyl chloride / 1,4-dioxane / 1 h / 20 °C

2.2: 16 h / 100 °C

3.1: ethyl acetate; N,N-dimethyl-formamide / 16 h / 20 °C

With thionyl chloride; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide;