N-{[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}-D-leucine

Base Information

Chemical Name:N-{[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}-D-leucine
CAS No.:1000872-33-2
Molecular Formula:C₂₃H₃₀ClFN₂O₈S
Molecular Weight:549.017
Hs Code.:

Synonyms:N-{[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}-D-leucine

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Chemical Property of N-{[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}-D-leucine

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Technology Process of N-{[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}-D-leucine

There total 4 articles about N-{[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}-D-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000872-32-1
benzyl N-{[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}-D-leucinate

: 1000872-33-2
N-{[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}-D-leucine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1.5h;

Reference yield:

: 1000872-49-0
benzyl N-[(chloromethoxy)carbonyl]-D-leucinate

: 1000872-33-2
N-{[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}-D-leucine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium iodide / acetonitrile / 1.5 h / 60 °C

2: potassium carbonate / acetonitrile / 2.5 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h / 20 °C

With hydrogen; potassium carbonate; sodium iodide; palladium 10% on activated carbon; In methanol; acetonitrile;

Reference yield:

: 17664-93-6
(R)-benzyl 2-amino-4-methylpentanoate p-toluenesulfonate salt

: 1000872-33-2
N-{[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}-D-leucine

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / diethyl ether / 5.67 h / 0 °C

2: sodium iodide / acetonitrile / 1.5 h / 60 °C

3: potassium carbonate / acetonitrile / 2.5 h / 20 °C

4: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h / 20 °C

With pyridine; hydrogen; potassium carbonate; sodium iodide; palladium 10% on activated carbon; In methanol; diethyl ether; acetonitrile;