1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidin-4-one

Base Information

Chemical Name:1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidin-4-one
CAS No.:1351815-54-7
Molecular Formula:C₂₉H₂₉NO₄
Molecular Weight:455.554
Hs Code.:

Synonyms:1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidin-4-one

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Chemical Property of 1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidin-4-one

Chemical Property:

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Technology Process of 1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidin-4-one

There total 8 articles about 1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 912545-08-5
2,4-bis-benzyloxy-5-isopropenyl-benzoic acid methyl ester

: 1351815-54-7
1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; methanol / 20 h / 75 °C

1.2: 0.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 23 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 20 °C

With methanol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In dichloromethane;

Reference yield:

: 1351815-53-6
[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl](4-hydroxypiperidin-1-yl)methanone

: 1351815-54-7
1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidin-4-one

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃;

Reference yield:

: 2150-47-2
methyl 2,4-dihydroxybenzoate

: 1351815-54-7
1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidin-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap / 1 h / 55 °C

2.1: trifluorormethanesulfonic acid / toluene / 2.5 h / 20 °C / Cooling with ice

2.2: 18 h / 20 °C

3.1: potassium carbonate / acetonitrile / 42 h / 75 °C

4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

4.2: 0.5 h

5.1: potassium hydroxide; methanol / 20 h / 75 °C

5.2: 0.5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 23 h / 20 °C

7.1: Dess-Martin periodane / dichloromethane / 20 °C

With methanol; trifluorormethanesulfonic acid; potassium tert-butylate; potassium carbonate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dmap; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;