7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-imidazolidine-2',4'-dione

Base Information

Chemical Name:7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-imidazolidine-2',4'-dione
CAS No.:620598-05-2
Molecular Formula:C₂₆H₂₃N₃O₅
Molecular Weight:457.486
Hs Code.:

Synonyms:7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-imidazolidine-2',4'-dione

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Chemical Property of 7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-imidazolidine-2',4'-dione

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Technology Process of 7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-imidazolidine-2',4'-dione

There total 3 articles about 7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-imidazolidine-2',4'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: ammonium bicarbonate

: 620598-02-9
1-benzyloxycarbonyl-7-benzyloxy-3,4-dihydro-2H-quinolin-4-one

: 620598-05-2
7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-imidazolidine-2',4'-dione

Guidance literature:: With potassium cyanide; In ethanol; for 72h; Heating / reflux;

Reference yield: 85.0%

: 151-50-8
potassium cyanide

: 620598-02-9
1-benzyloxycarbonyl-7-benzyloxy-3,4-dihydro-2H-quinolin-4-one

: 620598-05-2
7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-imidazolidine-2',4'-dione

Guidance literature:: In ethanol; for 72h; Heating;
DOI:10.1016/j.bmc.2003.08.022

Reference yield:

: 620597-98-0
N-(3-(benzyloxy)phenyl)-3-bromopropanamide

: 620598-05-2
7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-imidazolidine-2',4'-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / KOH; tetrabutylammonium bromide / CH₂Cl₂ / 3 h / 20 °C

2: 30 percent / polyphosphoric ester / 1,2-dichloro-ethane / 1.5 h / Heating

3: 98 percent / DIPEA / CH₂Cl₂ / 48 h

4: 85 percent / aq. ethanol / 72 h / Heating

With potassium hydroxide; polyphosphoric ester; tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2003.08.022