7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-methyl-imidazolidine-2',4'-dione

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Chemical Name:7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-methyl-imidazolidine-2',4'-dione
CAS No.:620598-24-5
Molecular Formula:C₂₇H₂₅N₃O₅
Molecular Weight:471.513
Hs Code.:

Synonyms:7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-methyl-imidazolidine-2',4'-dione

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Chemical Property of 7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-methyl-imidazolidine-2',4'-dione

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Technology Process of 7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-methyl-imidazolidine-2',4'-dione

There total 3 articles about 7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-methyl-imidazolidine-2',4'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 74-88-4
methyl iodide

: 620598-05-2
7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-imidazolidine-2',4'-dione

: 620598-24-5
7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-methyl-imidazolidine-2',4'-dione

Guidance literature:: With cesium bicarbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmc.2003.08.022

Reference yield:

: 620597-98-0
N-(3-(benzyloxy)phenyl)-3-bromopropanamide

: 620598-24-5
7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-methyl-imidazolidine-2',4'-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / KOH; tetrabutylammonium bromide / CH₂Cl₂ / 3 h / 20 °C

2: 30 percent / polyphosphoric ester / 1,2-dichloro-ethane / 1.5 h / Heating

3: 98 percent / DIPEA / CH₂Cl₂ / 48 h

4: 85 percent / aq. ethanol / 72 h / Heating

5: 79 percent / CsHCO₃ / dimethylformamide / 20 °C

With potassium hydroxide; cesium bicarbonate; polyphosphoric ester; tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2003.08.022

Reference yield:

: 620598-02-9
1-benzyloxycarbonyl-7-benzyloxy-3,4-dihydro-2H-quinolin-4-one

: 620598-24-5
7-benzyloxy-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester-4-spiro-5'-3'-methyl-imidazolidine-2',4'-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / aq. ethanol / 72 h / Heating

2: 79 percent / CsHCO₃ / dimethylformamide / 20 °C

With cesium bicarbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2003.08.022