Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride, 5,7-dimethyl- (9CI)

Base Information

• Chemical Name: Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride, 5,7-dimethyl- (9CI)
• CAS No.: 114040-07-2
• Molecular Formula: C9H8 Cl N3 O
• Molecular Weight: 209.635
• Mol file: 114040-07-2.mol

Synonyms:5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carbonylchloride

Chemical Property of Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride, 5,7-dimethyl- (9CI)

Chemical Property:

• PSA: 47.26000
• LogP: 1.72510

Purity/Quality:

98%min ^*data from raw suppliers

5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride, 5,7-dimethyl- (9CI)

There total 3 articles about Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride, 5,7-dimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5,7-dimethyl-pyrazolo[1,5-a] pyrimidine-3-carboxylic acid (90349-23-8) → 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carbonyl chloride (114040-07-2)

Guidance literature:

With oxalyl dichloride; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

acetylacetone (123-54-6,81235-32-7) → 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carbonyl chloride (114040-07-2)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 16 h / Reflux

2: sodium hydroxide / methanol / 5 h / 80 °C

3: oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C

With oxalyl dichloride; acetic acid; sodium hydroxide; In methanol; dichloromethane;

Reference yield:

ethyl 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylate (52664-01-4) → 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carbonyl chloride (114040-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 5 h / 80 °C

2: oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C

With oxalyl dichloride; sodium hydroxide; In methanol; dichloromethane;

upstream raw materials:

acetylacetone

ethyl 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylate

5,7-dimethyl-pyrazolo[1,5-a] pyrimidine-3-carboxylic acid

Refernces