N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-chloro-6-methoxyquinoline

Base Information

Chemical Name:N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-chloro-6-methoxyquinoline
CAS No.:1600518-09-9
Molecular Formula:C₂₈H₂₅ClN₂O₅S
Molecular Weight:537.036
Hs Code.:

Synonyms:N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-chloro-6-methoxyquinoline

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Chemical Property of N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-chloro-6-methoxyquinoline

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Technology Process of N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-chloro-6-methoxyquinoline

There total 4 articles about N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-chloro-6-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 4295-04-9
4-chloro-6-methoxyquinoline

: 541-41-3
chloroformic acid ethyl ester

: 312329-87-6
N-ethynyl-N-phenyl-4-methyl-benzenesulfonamide

: 1600518-09-9
N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-chloro-6-methoxyquinoline

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 2.5h; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo500365h

Reference yield:

: 68-34-8
phenyl toluenesulfonamide

: 1600518-09-9
N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-chloro-6-methoxyquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide

2: triphenylphosphine

3: n-butyllithium

4: copper(l) iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 25 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; In dichloromethane;
DOI:10.1021/jo500365h

Reference yield:

: 68984-88-3
N-Formyl-N-phenyl-4-methyl-benzenesulfonamide

: 1600518-09-9
N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-chloro-6-methoxyquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine

2: n-butyllithium

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 25 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane;
DOI:10.1021/jo500365h