N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfinylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine

Base Information

Chemical Name:N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfinylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine
CAS No.:1275595-86-2
Molecular Formula:C₂₉H₂₆ClFN₄O₃S
Molecular Weight:565.068
Hs Code.:

Synonyms:N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfinylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfinylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfinylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine

There total 14 articles about N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfinylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

: 60501-55-5
2-methanesulfinylethan-1-amine hydrochloride

: 231278-84-5
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

: 1275595-86-2
N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfinylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine

Guidance literature:: 2-methanesulfinylethan-1-amine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde; With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 50 - 60 ℃; for 1h;

With sodium cyanoborohydride; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 2.5h;

Reference yield: 91.1%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 6-(furan-2-yl)-4-[3-chloro-4-(3-fluorobenzyloxy)phenyl]aminoquinazoline

: 60501-55-5
2-methanesulfinylethan-1-amine hydrochloride

: 1275595-86-2
N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfinylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine

Guidance literature:: In tetrahydrofuran; at 35 - 40 ℃; for 4h;

Reference yield: 69.0%

: 388082-75-5
5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde 4-methylbenzenesulfonate

: 60501-55-5
2-methanesulfinylethan-1-amine hydrochloride

: 1275595-86-2
N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfinylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine

Guidance literature:: 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde 4-methylbenzenesulfonate; With triethylamine; In methanol; dichloromethane; for 0.166667h;

2-methanesulfinylethan-1-amine hydrochloride; With sodium tetrahydroborate; In methanol; dichloromethane; at 20 ℃; Cooling with ice;