2-methyl-1H-pyrrolo[3,2-c]pyridine

Base Information

• Chemical Name: 2-methyl-1H-pyrrolo[3,2-c]pyridine
• CAS No.: 113975-37-4
• Molecular Formula: C8H8 N2
• Molecular Weight: 132.165
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID20554999
• Nikkaji Number: J981.295D
• Wikidata: Q82436208
• Mol file: 113975-37-4.mol

Synonyms:2-methyl-1H-pyrrolo[3,2-c]pyridine;113975-37-4;2-Methyl-5-azaindole;1H-PYRROLO[3,2-C]PYRIDINE, 2-METHYL-;2-Methyl-1H-pyrrolo[2,3-d]pyridine;1H-Pyrrolo[3,2-c]pyridine,2-methyl-(9CI);SCHEMBL4805509;DTXSID20554999;PSEAZIPYGNUYPC-UHFFFAOYSA-N;MFCD12923617;AKOS015999208;CS-W021718;PB34737;AS-33275;EN300-342160;A803116;Z1255388194

Chemical Property of 2-methyl-1H-pyrrolo[3,2-c]pyridine

Chemical Property:

• Vapor Pressure: 0.0113mmHg at 25°C
• Melting Point: 210 °C
• Refractive Index: 1.666
• Boiling Point: 270.5°C at 760 mmHg
• PKA: 15.77±0.40(Predicted)
• Flash Point: 119°C
• PSA: 28.68000
• Density: 1.186g/cm³
• LogP: 1.87130
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 132.068748264
• Heavy Atom Count: 10
• Complexity: 124

Purity/Quality:

97% ^*data from raw suppliers

2-Methyl-5-azaindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(N1)C=CN=C2
• Uses: 2-methyl-1H-pyrrolo[3,2-c]pyridine is an azaindole derivative used for the preparation of pyrrolopyridine derivatives for treating diseases mediated by prostaglandin D2 (PGD2).

Technology Process of 2-methyl-1H-pyrrolo[3,2-c]pyridine

There total 21 articles about 2-methyl-1H-pyrrolo[3,2-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(3-prop-1-ynyl-pyridin-4-yl)-carbamic acid tert-butyl ester (211029-71-9) → 2-methyl-1H-pyrrolo[3,2-c]pyridine (113975-37-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 15h;

Reference yield: 74.0%

tert-butyl 2-methyl-1H-pyrrolo[3,2-c]pyridine-1-carboxylate (211029-77-5) → 2-methyl-1H-pyrrolo[3,2-c]pyridine (113975-37-4)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 16 - 18h;

Reference yield: 61.0%

4-amino-3-(1-propynyl)pyridine (449173-27-7) → 2-methyl-1H-pyrrolo[3,2-c]pyridine (113975-37-4)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

N-(3-methylpyridin-4-yl)acetamide

sodium ethanolate

2,2-dimethyl-N-<3-(2-oxopropyl)-4-pyridinyl>propanamide

(3-prop-1-ynyl-pyridin-4-yl)-carbamic acid tert-butyl ester

Downstream raw materials:

[3-(4-chloro-phenylsulfanyl)-2-methyl-pyrrolo[3,2-c]pyridin-1-yl]-acetic acid ethyl ester

[3-(4-chloro-phenylsulfonyl)-2-methyl-pyrrolo[3,2-c]pyridin-1-yl]-acetic acid ethyl ester

[3-(4-chloro-phenylsulfonyl)-2-methyl-5-oxy-pyrrolo[3,2-c]pyridin-1-yl]-acetic acid ethyl ester

2-Cyclopropyl-4-(5-fluoro-2-methylphenyl)-4-methyl-1-(1H-pyrrolo[3,2-c]pyridin-2-yl)pentan-2-ol