1H-Imidazole-4-propanoic acid, hydrazide (9CI)

Base Information

• Chemical Name: 1H-Imidazole-4-propanoic acid, hydrazide (9CI)
• CAS No.: 113872-16-5
• Molecular Formula: C₆H₁₀N₄O
• Molecular Weight: 154.172
• Mol file: 113872-16-5.mol

Synonyms:1H-Imidazole-4-propanoicacid, hydrazide (9CI)

Chemical Property of 1H-Imidazole-4-propanoic acid, hydrazide (9CI)

Chemical Property:

• Refractive Index: 1.584
• PSA: 87.29000
• LogP: 0.87280

Purity/Quality:

98%Min ^*data from raw suppliers

1H-Imidazole-5-propanoic acid hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1H-Imidazole-4-propanoic acid, hydrazide (9CI) is used for the preparation of coupling reagent for derivatization of Cortisol (H714615).

Technology Process of 1H-Imidazole-4-propanoic acid, hydrazide (9CI)

There total 8 articles about 1H-Imidazole-4-propanoic acid, hydrazide (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-(4-imidazolyl)propionate (31434-93-2) → 3-(4-imidazolyl)propionic acid hydrazide (113872-16-5)

Guidance literature:

With hydrazine hydrate; In hydrogenchloride; methanol; at 70 ℃; for 2h;

DOI:10.1248/cpb.35.5000

Reference yield:

urocanic Acid (3465-72-3) → 3-(4-imidazolyl)propionic acid hydrazide (113872-16-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 0.5N NaOH; 2.) cc. HCl / 10percent palladium-on-charcoal / 1.) 2 h;

2: HCl / 2 h / Heating

3: 0.8 g / 100percent hydrazine hydrate / methanol; HCl / 2 h / 70 °C

With hydrogenchloride; sodium hydroxide; hydrazine hydrate; palladium on activated charcoal; In hydrogenchloride; methanol;

DOI:10.1248/cpb.35.5000

Reference yield:

3-(4-imidazolyl)propionic acid monohydrochloride (53958-93-3) → 3-(4-imidazolyl)propionic acid hydrazide (113872-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / 2 h / Heating

2: 0.8 g / 100percent hydrazine hydrate / methanol; HCl / 2 h / 70 °C

With hydrogenchloride; hydrazine hydrate; In hydrogenchloride; methanol;

DOI:10.1248/cpb.35.5000

upstream raw materials:

ethyl 3-(imidazol-4'-yl)-propanoate

3-(2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-acrylic acid

3-(2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-propionic acid

3-(imidazol-4-yl)propionic acid

Refernces