31434-93-2

Basic information

• Product Name: METHYL 3-(1H-IMIDAZOL-4-YL)-PROPANOATE HYDROCHLORIDE
• Synonyms: 3-(1H-Imidazol-4-yl)propionic acid methyl ester;Methyl 3-(imidazol-4-yl)propanoate;Methyl 4-imidazolepropionate;Methyl imidazolepropionate;1H-IMidazole-4-propanoicacid,Methylester,Monohydrochloride;methyl 3-(1H-imidazol-5-yl)propanoate;METHYL 3-(1H-IMIDAZOL-4-YL)-PROPANOATE HYDROCHLORIDE;Methyl 3-(IMidazol-4-yl) Propionate (HCL)
• CAS NO: 31434-93-2
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 190.63
• Product Categories: Miscellaneous Reagents;Intermediates
• Mol File: 31434-93-2.mol
• Article Data: 23

Chemical Properties

• Melting Point: 42-45?C
• Boiling Point: 328℃
• Flash Point: 152℃
• Appearance: /
• Density: 1.183
• Vapor Pressure: 2.37E-05mmHg at 25°C
• Storage Temp.: Refrigerator
• PKA: 14.00±0.10(Predicted)
• CAS DataBase Reference: METHYL 3-(1H-IMIDAZOL-4-YL)-PROPANOATE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-(1H-IMIDAZOL-4-YL)-PROPANOATE HYDROCHLORIDE(31434-93-2)
• EPA Substance Registry System: METHYL 3-(1H-IMIDAZOL-4-YL)-PROPANOATE HYDROCHLORIDE(31434-93-2)

Safety Data

• Hazardous Substances Data: 31434-93-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-White hygroscopic solid

Uses

Methyl 3-(Imidazol-4-yl) Propionate (cas# 31434-93-2) is a compound useful in organic synthesis.

InChI:InChI=1/C7H10N2O2.ClH/c1-11-7(10)3-2-6-4-8-5-9-6;/h4-5H,2-3H2,1H3,(H,8,9);1H

Upstream product

• 67-56-1 methanol 
• 53958-93-3 3-(4-imidazolyl)propionic acid monohydrochloride 
• 345626-09-7 4(5)-<2-(methoxycarbonyl)ethenyl>-N-carbobenzoxyimidazole 
• 1074-59-5 3-(imidazol-4-yl)propionic acid 
• 52838-22-9 methyl 3-[1H-imidazol-4-yl]propenoate hydrochloride salt 
• 70346-51-9 methyl (E)-3-(1H-imidazol-5-yl)prop-2-enoate 
• 1074-59-5 3-(1H-imidazol-5-yl)propanoic acid 
• 3465-72-3 (E)-3-(1H-imidazol-4-yl)propenoic acid 
• 104-98-3 urocanic acid 
• 160073-02-9 methyl 3-(imidazol-4⁽⁵⁾-yl)-2-propenoate 
• 70346-51-9 (E)-methyl 3-(1H-imidazol-4-yl)acrylate 
• 345624-98-8 4-((E)-2-Carboxy-vinyl)-imidazole-1-carboxylic acid benzyl ester 
• 3465-72-3 urocanic Acid 
• 54260-89-8 trans-4-imidazoleacrylic acid methyl ester hydrochloride 

Downstream Products

• 186096-16-2 methyl 3-(1-tritylimidazol-4-yl)propionate 
• 49549-75-9 4-(3-hydroxypropyl)-1H-imidazole 
• 1074-59-5 3-(imidazol-4-yl)propionic acid 
• 1274939-77-3 Br^(1-)*C₅₃H₄₅N₆O₂⁽¹⁺⁾ 
• 1274939-78-4 Br^(1-)*C₅₃H₄₅N₆O₂⁽¹⁺⁾ 
• 1274939-79-5 Br^(1-)*C₅₃H₄₅N₆O₂⁽¹⁺⁾ 
• 1160845-94-2 methyl 3-(1-benzyl-1H-imidazol-4-yl)propanoate 
• 1373501-33-7 4-(3-methoxy-3-oxopropyl)-1,3-dibenzyl-1H-imidazol-3-ium bromide 
• 1373501-37-1 3-butyl-4-(3-methoxy-3-oxopropyl)-1-benzyl-1H-imidazol-3-ium bromide 
• 102676-62-0 4-<3-<4-<(tert-butylamino)carbonyl>phenyl>-3-hydroxyprop-1-yl>-1-(triphenylmethyl)-1H-imidazole 
• 102676-63-1 4-<3-<4-<(tert-butylamino)carbonyl>phenyl>-3-chloroprop-1-yl>-1-(triphenylmethyl)-1H-imidazole 
• 102676-65-3 5-(4-cyanophenyl)-6,7-dihydro-5H-pyrrolo<1,2-c>imidazole hydrochloride 
• 102676-68-6 ethyl 5-<1-(triphenylmethyl)-1H-imidazol-4-yl>-1-pentanoate 
• 102676-67-5 ethyl 5-<1-(triphenylmethyl)-1H-imidazol-4-yl>-1-pent-2-enoate 

Relevant articles and documents

Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease

A series of novel propargylamine-modified pyrimidinylthiourea derivatives (1–3) were designed and synthesized as multifunctional agents for Alzheimer's disease (AD) therapy, and their potential was evaluated through various biological experiments. Among these derivatives, compound 1b displayed good selective inhibitory activity against AChE (vs BuChE, IC50 = 0.324 μM, SI > 123) and MAO-B (vs MAO-A, IC50 = 1.427 μM, SI > 35). Molecular docking study showed that the pyrimidinylthiourea moiety of 1b could bind to the catalytic active site (CAS) of AChE, and the propargylamine moiety interacted directly with the flavin adenine dinucleotide (FAD) of MAO-B. Moreover, 1b demonstrated mild antioxidant ability, good copper chelating property, effective inhibitory activity against Cu2+-induced Aβ1?42 aggregation, moderate neuroprotection, low cytotoxicity, and appropriate blood?brain barrier (BBB) permeability in vitro and was capable of ameliorating scopolamine-induced cognitive impairment in mice. These results indicated that 1b has the potential to be a multifunctional candidate for the treatment of Alzheimer's disease.

Nickel-Catalyzed Reversible Functional Group Metathesis between Aryl Nitriles and Aryl Thioethers

We describe a new functional group metathesis between aryl nitriles and aryl thioethers. The catalytic system nickel/dcype is essential to achieve this fully reversible transformation in good to excellent yields. Furthermore, the cyanide- and thiol-free reaction shows high functional group tolerance and great efficiency for the late-stage derivatization of commercial molecules. Finally, synthetic applications demonstrate its versatility and utility in multistep synthesis.

NRF2 REGULATORS

The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.