[(S)-1-((R)-5-Benzyl-5-methyl-4-oxo-4,5-dihydro-1H-pyrrol-2-yl)-1-hydroxymethyl-2-methyl-propyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(S)-1-((R)-5-Benzyl-5-methyl-4-oxo-4,5-dihydro-1H-pyrrol-2-yl)-1-hydroxymethyl-2-methyl-propyl]-carbamic acid tert-butyl ester
CAS No.:181861-95-0
Molecular Formula:C₂₂H₃₂N₂O₄
Molecular Weight:388.507
Hs Code.:

Synonyms:[(S)-1-((R)-5-Benzyl-5-methyl-4-oxo-4,5-dihydro-1H-pyrrol-2-yl)-1-hydroxymethyl-2-methyl-propyl]-carbamic acid tert-butyl ester

Suppliers and Price of [(S)-1-((R)-5-Benzyl-5-methyl-4-oxo-4,5-dihydro-1H-pyrrol-2-yl)-1-hydroxymethyl-2-methyl-propyl]-carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(S)-1-((R)-5-Benzyl-5-methyl-4-oxo-4,5-dihydro-1H-pyrrol-2-yl)-1-hydroxymethyl-2-methyl-propyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(S)-1-((R)-5-Benzyl-5-methyl-4-oxo-4,5-dihydro-1H-pyrrol-2-yl)-1-hydroxymethyl-2-methyl-propyl]-carbamic acid tert-butyl ester

There total 5 articles about [(S)-1-((R)-5-Benzyl-5-methyl-4-oxo-4,5-dihydro-1H-pyrrol-2-yl)-1-hydroxymethyl-2-methyl-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 181861-94-9
[(S)-1-((R)-5-Benzyl-5-methyl-4-oxo-4,5-dihydro-1H-pyrrol-2-yl)-1-benzyloxymethyl-2-methyl-propyl]-carbamic acid tert-butyl ester

: 181861-95-0
[(S)-1-((R)-5-Benzyl-5-methyl-4-oxo-4,5-dihydro-1H-pyrrol-2-yl)-1-hydroxymethyl-2-methyl-propyl]-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; for 24h; under 760 Torr; Ambient temperature;
DOI:10.1016/0968-0896(96)00094-6

Reference yield:

: ((R)-1-Benzyloxymethyl-2-hydroxy-1-isopropyl-propyl)-carbamic acid tert-butyl ester

: 181861-95-0
[(S)-1-((R)-5-Benzyl-5-methyl-4-oxo-4,5-dihydro-1H-pyrrol-2-yl)-1-hydroxymethyl-2-methyl-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: molecular sieves 4 Angstroem, NMO, TPAP / CH₂Cl₂ / 1 h / Ambient temperature

2: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C

3: Dess-Martin periodinane, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

4: 88 percent / H₂ / 5percent Pd/C / methanol / 6 h / 760 Torr / Ambient temperature

5: H₂ / 20percent Pd(OH)2/C / methanol / 24 h / 760 Torr / Ambient temperature

With pyridine; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; hydrogen; Dess-Martin periodane; lithium hexamethyldisilazane; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0968-0896(96)00094-6

Reference yield:

: 181861-89-2
((R)-1-Benzyloxymethyl-1-formyl-2-methyl-propyl)-carbamic acid tert-butyl ester

: 181861-95-0
[(S)-1-((R)-5-Benzyl-5-methyl-4-oxo-4,5-dihydro-1H-pyrrol-2-yl)-1-hydroxymethyl-2-methyl-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether; tetrahydrofuran / 1 h / -78 °C

2: molecular sieves 4 Angstroem, NMO, TPAP / CH₂Cl₂ / 1 h / Ambient temperature

3: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C

4: Dess-Martin periodinane, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

5: 88 percent / H₂ / 5percent Pd/C / methanol / 6 h / 760 Torr / Ambient temperature

6: H₂ / 20percent Pd(OH)2/C / methanol / 24 h / 760 Torr / Ambient temperature

With pyridine; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; hydrogen; Dess-Martin periodane; lithium hexamethyldisilazane; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/0968-0896(96)00094-6