4-chloro-2-(5-chlorothiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Base Information

Chemical Name:4-chloro-2-(5-chlorothiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine
CAS No.:1249768-08-8
Molecular Formula:C₁₁H₈Cl₂N₂S
Molecular Weight:271.17
Hs Code.:

Synonyms:4-chloro-2-(5-chlorothiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Suppliers and Price of 4-chloro-2-(5-chlorothiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 4-chloro-2-(5-chlorothiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 4-chloro-2-(5-chlorothiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

There total 1 articles about 4-chloro-2-(5-chlorothiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50478-16-5
5-chlorothiophene-2-carbonitrile

: 1249768-08-8
4-chloro-2-(5-chlorothiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 3 h / 20 °C

1.2: 48 h / 20 °C

2.1: sodium methylate / ethanol; methanol / 20 h / Reflux

3.1: trichlorophosphate / 4 h / 90 °C

With sodium methylate; trichlorophosphate; In methanol; ethanol;

Reference yield: 88.0%

: 1249768-08-8
4-chloro-2-(5-chlorothiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

: 2-(4-amino-3-hydroxyphenyl)acetic acid methyl ester acetate

: 2-(4-(2-(5-chlorothiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-ylamino)-3-hydroxyphenyl)acetic acid methyl ester

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 100 ℃; for 3h; Inert atmosphere;

Reference yield: 76.0%

: 1249768-08-8
4-chloro-2-(5-chlorothiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

: 104126-70-7
2-(4-amino-3-nitrophenyl)acetic acid ethyl ester

: 2-(4-(2-(5-chlorothiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-ylamino)-3-nitrophenyl)acetic acid ethyl ester

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 100 ℃; for 2h;