104126-70-7

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 4-amino-3-nitrophenylacetate is used as an intermediate in the synthesis of pharmaceuticals for its role in the production of therapeutic agents such as analgesics and antipyretics. Its versatile reactivity allows for the creation of various biologically active compounds, contributing to the development of new medications.
Used in Dye Industry:
Ethyl 4-amino-3-nitrophenylacetate is used as an intermediate in the synthesis of dyes, where its chemical properties enable the production of pigments and specialty chemicals. This contributes to the coloration and enhancement of various products in the dye industry.
Used in Organic Chemistry Research:
Ethyl 4-amino-3-nitrophenylacetate is used as a subject of study in organic chemistry research due to its potential application in the synthesis of various biologically active compounds. Its unique structure and reactivity make it a valuable compound for exploring new chemical reactions and developing innovative applications.

Upstream product

• 64-17-5 ethanol 
• 116435-82-6 2-(4-amino-3-nitrophenyl)acetic acid 
• 18699-02-0 4-acetamidophenylacetic acid 
• 90916-02-2 4-Acetamino-3-nitro-phenylessigsaeure 
• 92959-74-5 ethyl 2-(4-acetamido-3-nitrophenyl)acetate 
• 13475-17-7 ethyl 2-(4-acetamidophenyl)acetate 
• 5438-70-0 ethyl (4-amino-3,5-dibromophenyl)acetate 

Downstream Products

• 104125-49-7 4-pyrrolidin-1-ylcarbonylmethyl-o-phenylenediamine 
• 473895-87-3 ethyl ester of quinoxalin-6-ylacetic acid 
• 726207-08-5 C₂₅H₂₀ClN₃O₇S 
• 726207-09-6 C₂₅H₂₂ClN₃O₅S 
• 726206-84-4 C₁₈H₁₄N₂O₆ 
• 219519-06-9 N-(3-cyanobenzoyl)-4-(ethoxycarbonylmethyl)-2-nitroaniline 

Relevant academic research and scientific papers

Indole and indazole compounds as an inhibitor of cellular necrosis

The present invention refers to a formula (1) compounds of, pharmaceutically acceptable salts or isomers thereof thereof, and characterized by by containing as active ingredients-associated diseases, cell death and method for the prevention or treatment of relates and compositions. [Formula 1] In formula said R 1, R 2, R 3, R 4, R 5, R 6, A, X, n and m to equal the specification.

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORy.

Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors

We previously reported on a series of cyclohexanediamine derivatives as highly potent factor Xa inhibitors. Herein, we describe the modification of the spacer moiety to discover an alternative scaffold. Ethylenediamine derivatives possessing a substituent at the C1 position in S configuration and phenylenediamine derivatives possessing a substituent at the C5 position demonstrated moderate to strong anti-fXa activity. Further SAR studies led to the identification of compound 30h which showed both good in vitro activity (fXa IC50 = 2.2 nM, PTCT2 = 3.9 μM) and in vivo antithrombotic efficacy.

INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.

INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.

FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS

The present invention provides a method for treating a thrombotic or an inflammatory disorder administering to a patient in need thereof a therapeutically effective amount of at least one compound of Formula (I) or Formula (V): (I) [INSERTCHEMICAL STRUCTURE HERE] (V)[INSERT CHEMICAL STRUCTURE HERE] or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R3, R4, R6, R11, X1, X2, and X3 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also provides compounds within the scope of Formula I and relates to pharmaceutical compositions comprising these compounds.

Tetrahydropyridly-alkyl-heterocycles, method for preparing same and pharmaceutical compositions containing same

The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independently represent a hydrogen atom or a methyl gr