3-(m-tolyl)-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole

Base Information

• Chemical Name: 3-(m-tolyl)-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole
• CAS No.: 1439921-22-8
• Molecular Formula: C₁₂H₁₂F₃NO
• Molecular Weight: 243.229
• Mol file: 1439921-22-8.mol

Synonyms:3-(m-tolyl)-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole

Chemical Property of 3-(m-tolyl)-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-(m-tolyl)-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole

There total 2 articles about 3-(m-tolyl)-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(m-tolyl)but-3-en-1-one oxime (1439921-55-7) + (trifluoromethyl)trimethylsilane (81290-20-2) → 3-(m-tolyl)-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole (1439921-22-8)

Guidance literature:

(trifluoromethyl)trimethylsilane; With copper (I) acetate; cesium fluoride; In acetonitrile; at 20 ℃; for 0.5h; Inert atmosphere; Sealed tube;

With 1,10-Phenanthroline; In acetonitrile; at 20 ℃; for 0.5h; Inert atmosphere; Sealed tube;

1-(m-tolyl)but-3-en-1-one oxime; With trichloroisocyanuric acid; In acetonitrile; at 20 ℃; for 10h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.6b03582

Reference yield: 61.0%

Togni's reagent II (887144-94-7) + 1-(m-tolyl)but-3-en-1-one oxime (1439921-55-7) → 3-(m-tolyl)-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole (1439921-22-8)

Guidance literature:

With sodium acetate; copper(l) chloride; In N,N-dimethyl-formamide; at 50 ℃; for 0.5h; Inert atmosphere;

DOI:10.1039/c3cc42588f

upstream raw materials:

Togni's reagent II

1-(m-tolyl)but-3-en-1-one oxime

(trifluoromethyl)trimethylsilane