methyl trans-1-(2-amino-ethylamino)-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

Base Information

Chemical Name:methyl trans-1-(2-amino-ethylamino)-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate
CAS No.:1178976-78-7
Molecular Formula:C₂₅H₂₉ClFN₅O₄
Molecular Weight:517.988
Hs Code.:

Synonyms:methyl trans-1-(2-amino-ethylamino)-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

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Chemical Property of methyl trans-1-(2-amino-ethylamino)-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

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Technology Process of methyl trans-1-(2-amino-ethylamino)-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

There total 10 articles about methyl trans-1-(2-amino-ethylamino)-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1178976-82-3
methyl trans-1-(2-tert.-butoxycarbonylamino-ethylamino)-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

: 1178976-78-7
methyl trans-1-(2-amino-ethylamino)-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

Guidance literature:: methyl trans-1-(2-tert.-butoxycarbonylamino-ethylamino)-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

With potassium carbonate; In methanol; dichloromethane; water;

Reference yield:

: 808793-56-8
3-benzyl-6-hydroxy-7-methoxy-3H-quinazolin-4-one

: 1178976-78-7
methyl trans-1-(2-amino-ethylamino)-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 - 80 °C

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / 60 °C

3.1: triethylamine; trichlorophosphate / acetonitrile / 2 h / 40 °C / Inert atmosphere; Reflux

3.2: 20 - 40 °C / Inert atmosphere

3.3: 20 °C

4.1: ethanol; water / 4 h / Reflux

5.1: sodium hydroxide; water / 25 h / 135 °C

5.2: 20 °C

6.1: thionyl chloride / Cooling with ice; Reflux

7.1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With thionyl chloride; water; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 141120-33-4
8-methylsulfonyloxy-1,4-dioxaspiro[4.5]decane

: 1178976-78-7
methyl trans-1-(2-amino-ethylamino)-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 - 80 °C

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / 60 °C

3.1: triethylamine; trichlorophosphate / acetonitrile / 2 h / 40 °C / Inert atmosphere; Reflux

3.2: 20 - 40 °C / Inert atmosphere

3.3: 20 °C

4.1: ethanol; water / 4 h / Reflux

5.1: sodium hydroxide; water / 25 h / 135 °C

5.2: 20 °C

6.1: thionyl chloride / Cooling with ice; Reflux

7.1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With thionyl chloride; water; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;