methyl (3-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetate

Base Information

Chemical Name:methyl (3-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetate
CAS No.:1092938-73-2
Molecular Formula:C₂₈H₂₄N₄O₄
Molecular Weight:480.523
Hs Code.:

Synonyms:methyl (3-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetate

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Chemical Property of methyl (3-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetate

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Technology Process of methyl (3-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetate

There total 10 articles about methyl (3-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.9%

: 1092938-83-4
5-ethyl-2-tributylstannyl pyridine

: 1092938-95-8
methyl {3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]phenoxy}acetate

: 1092938-73-2
methyl (3-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetate

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 48h; Reflux; Inert atmosphere;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1092938-73-2
methyl (3-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: diethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2: 1.5 h / 210 °C

3: N-Bromosuccinimide / tetrachloromethane / 60 °C

4: hydrogenchloride; isopentyl nitrite / 1,4-dioxane; chloroform / 3 h / Reflux

5: N-ethyl-N,N-diisopropylamine / 0.5 h / 180 °C / microwave irradiation

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 48 h / Reflux; Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; diethylamine; N-ethyl-N,N-diisopropylamine; isopentyl nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; tetrachloromethane; chloroform; N,N-dimethyl-formamide; toluene;

Reference yield:

: 554-84-7
meta-nitrophenol

: 1092938-73-2
methyl (3-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / acetone / 1 h / 50 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / 0.5 h / 180 °C / microwave irradiation

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 48 h / Reflux; Inert atmosphere

With hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; acetone; toluene;