homo-camptothecin-20-O-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]propionate

Base Information

Chemical Name:homo-camptothecin-20-O-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]propionate
CAS No.:631090-67-0
Molecular Formula:C₃₅H₃₃F₃N₄O₅
Molecular Weight:646.666
Hs Code.:

Synonyms:homo-camptothecin-20-O-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]propionate

Suppliers and Price of homo-camptothecin-20-O-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of homo-camptothecin-20-O-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]propionate

Chemical Property:

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Technology Process of homo-camptothecin-20-O-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]propionate

There total 2 articles about homo-camptothecin-20-O-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186668-40-6
5-ethyl-5-hydroxy-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione

: 435270-80-7
3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]-propionic acid

: 631090-67-0
homo-camptothecin-20-O-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]propionate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 15532-75-9
1-(3-Trifluoromethylphenyl)piperazine

: 631090-67-0
homo-camptothecin-20-O-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]propionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / ethanol / 3 h / Heating / reflux

1.2: 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 h / 20 °C

With dmap; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;