(3R,4R)-4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidin-1-ium TFA salt

Base Information

Chemical Name:(3R,4R)-4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidin-1-ium TFA salt
CAS No.:1548128-95-5
Molecular Formula:C₂HF₃O₂*C₈H₁₁FN₂O₂S
Molecular Weight:332.276
Hs Code.:

Synonyms:(3R,4R)-4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidin-1-ium TFA salt

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Chemical Property of (3R,4R)-4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidin-1-ium TFA salt

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Technology Process of (3R,4R)-4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidin-1-ium TFA salt

There total 1 articles about (3R,4R)-4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidin-1-ium TFA salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85838-94-4
N-Boc-1,2,3,6-tetrahydropyridine

: 1548128-95-5
(3R,4R)-4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidin-1-ium TFA salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 25 h / 0 - 20 °C

2.1: magnesium(II) perchlorate / N,N-dimethyl-formamide / 12.3 h / 20 - 115 °C

2.2: 23 h / 0 - 20 °C

3.1: Ciralpak AD / methanol / 30 °C / Resolution of racemate

4.1: dichloromethane / 6.3 h / 20 °C

With magnesium(II) perchlorate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/op400325r

Reference yield:

: 1548128-95-5
(3R,4R)-4-(2,4-dioxothiazolidin-3-yl)-3-fluoropiperidin-1-ium TFA salt

: 1548129-04-9
(Z)-5-((1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene)-3-((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)thiazolidine-2,4-dione hydrochloride salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane; water / 0.17 h / 20 °C

1.2: 0.17 h / 20 °C

1.3: 22 h / 20 °C

2.1: toluene / 0.08 h / 20 °C

2.2: 86 h / 111 - 113 °C / Darkness

3.1: hydrogenchloride / ethanol; tetrahydrofuran / 1.25 h / 20 - 24.6 °C

With hydrogenchloride; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/op400325r