3-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}-(Z)-acrylic acid methyl ester

Base Information

Chemical Name:3-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}-(Z)-acrylic acid methyl ester
CAS No.:1311146-54-9
Molecular Formula:C₁₉H₁₇BrF₂O₂
Molecular Weight:395.244
Hs Code.:

Synonyms:3-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}-(Z)-acrylic acid methyl ester

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Chemical Property of 3-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}-(Z)-acrylic acid methyl ester

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Technology Process of 3-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}-(Z)-acrylic acid methyl ester

There total 3 articles about 3-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}-(Z)-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1311146-49-2
2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylbenzaldehyde

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 1311146-54-9
3-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}-(Z)-acrylic acid methyl ester

: 1311146-53-8
3-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}-(E)-acrylic acid methyl ester

Guidance literature:: In benzene; at 50 ℃; for 6h; optical yield given as %de;
DOI:10.1016/j.tet.2011.03.073

Reference yield:

: 1311146-46-9
{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}methanol

: 1311146-54-9
3-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}-(Z)-acrylic acid methyl ester

: 1311146-53-8
3-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}-(E)-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran; dimethyl sulfoxide / 1 h / 40 °C

2: benzene / 6 h / 50 °C

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; benzene; 2: Wittig reaction;
DOI:10.1016/j.tet.2011.03.073

Reference yield:

: 1311146-41-4
2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylbenzoic acid ethyl ester

: 1311146-54-9
3-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}-(Z)-acrylic acid methyl ester

: 1311146-53-8
3-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}-(E)-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: lithium triethylborohydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran; dimethyl sulfoxide / 1 h / 40 °C

3: benzene / 6 h / 50 °C

With lithium triethylborohydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; benzene; 3: Wittig reaction;
DOI:10.1016/j.tet.2011.03.073