tert-butyl-{3-[2-(2-dimethoxymethyl-3,5-dimethoxybenzyl)-[1,3]dithian-2-yl]propoxy}dimethylsilane

Base Information

• Chemical Name: tert-butyl-{3-[2-(2-dimethoxymethyl-3,5-dimethoxybenzyl)-[1,3]dithian-2-yl]propoxy}dimethylsilane
• CAS No.: 606926-18-5
• Molecular Formula: C₂₅H₄₄O₅S₂Si
• Molecular Weight: 516.839
• Mol file: 606926-18-5.mol

Synonyms:tert-butyl-{3-[2-(2-dimethoxymethyl-3,5-dimethoxybenzyl)-[1,3]dithian-2-yl]propoxy}dimethylsilane

Chemical Property of tert-butyl-{3-[2-(2-dimethoxymethyl-3,5-dimethoxybenzyl)-[1,3]dithian-2-yl]propoxy}dimethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl-{3-[2-(2-dimethoxymethyl-3,5-dimethoxybenzyl)-[1,3]dithian-2-yl]propoxy}dimethylsilane

There total 5 articles about tert-butyl-{3-[2-(2-dimethoxymethyl-3,5-dimethoxybenzyl)-[1,3]dithian-2-yl]propoxy}dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

tert-butyl-(3-1,3-dithian-2-yl-propoxy)-dimethyl-silane (444816-13-1) + 1-chloromethyl-2-dimethoxymethyl-3,5-dimethoxybenzene (606926-17-4) → tert-butyl-{3-[2-(2-dimethoxymethyl-3,5-dimethoxybenzyl)-[1,3]dithian-2-yl]propoxy}dimethylsilane (606926-18-5)

Guidance literature:

tert-butyl-(3-1,3-dithian-2-yl-propoxy)-dimethyl-silane; With n-butyllithium; In tetrahydrofuran; at -78 - -20 ℃;

1-chloromethyl-2-dimethoxymethyl-3,5-dimethoxybenzene; In tetrahydrofuran;

DOI:10.1021/jo050414g

Reference yield:

2-(chloromethyl)-4,6-dimethoxy-benzaldehyde (166322-67-4) → tert-butyl-{3-[2-(2-dimethoxymethyl-3,5-dimethoxybenzyl)-[1,3]dithian-2-yl]propoxy}dimethylsilane (606926-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 95 percent / p-TsOH; molecular sieves 4 Angstroem / methanol / 50 °C

2.1: n-BuLi / tetrahydrofuran / -78 - -20 °C

2.2: 42 percent / tetrahydrofuran

With n-butyllithium; 4 A molecular sieve; toluene-4-sulfonic acid; In tetrahydrofuran; methanol;

DOI:10.1021/jo050414g

Reference yield:

3,5-dimethoxybenzyl alcohol (705-76-0) → tert-butyl-{3-[2-(2-dimethoxymethyl-3,5-dimethoxybenzyl)-[1,3]dithian-2-yl]propoxy}dimethylsilane (606926-18-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 87 percent / POCl₃ / 60 °C

2.1: 95 percent / p-TsOH; molecular sieves 4 Angstroem / methanol / 50 °C

3.1: n-BuLi / tetrahydrofuran / -78 - -20 °C

3.2: 42 percent / tetrahydrofuran

With n-butyllithium; 4 A molecular sieve; toluene-4-sulfonic acid; trichlorophosphate; In tetrahydrofuran; methanol;

DOI:10.1021/jo050414g

upstream raw materials:

tert-butyl-(3-1,3-dithian-2-yl-propoxy)-dimethyl-silane

1-chloromethyl-2-dimethoxymethyl-3,5-dimethoxybenzene

3,5-dimethoxybenzyl alcohol

2-(chloromethyl)-4,6-dimethoxy-benzaldehyde

Downstream raw materials:

tert-butyl-{3-[2-(2-dimethoxymethyl-3,5-dimethoxy-4-methylbenzyl)-[1,3]dithian-2-yl]propoxy}dimethylsilane

acetic acid 5-(2-formyl-3,5-dihydroxy-4-methylphenyl)-4-oxopentyl ester

acetic acid 5-(2-formyl-3,5-dimethoxy-4-methylphenyl)-4-oxopentyl ester

6-[2-(3-hydroxypropyl)[1,3]dithian-2-ylmethyl]-2,4-dimethoxy-3-methylbenzaldehyde