Technology Process of C38H37NO7S
There total 7 articles about C38H37NO7S which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-[2-(4'-methoxy-biphenyl-4-sulfonylamino)-ethyl]-naphthalene-1-carboxylic acid tert-butyl ester;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 ℃;
benzyl chloroformate;
In
N,N-dimethyl-formamide;
Further stages.;
DOI:10.1021/jm020160g
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tBuOK / tetrahydrofuran / 1 h / -78 °C
1.2: 87 percent / tetrahydrofuran / 16 h / 20 °C
2.1: 18 percent / aq. p-TsOH / dioxane / 2 h / Heating
3.1: 73 percent / NaBH4 / methanol / 2 h
4.1: Ph3P; DEAD / tetrahydrofuran
5.1: tBuLi / tetrahydrofuran; pentane / -78 °C
6.1: NaH / dimethylformamide / 0 °C
6.2: dimethylformamide
With
sodium tetrahydroborate; potassium tert-butylate; tert.-butyl lithium; sodium hydride; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; pentane;
4.1: Mitsunobu reaction;
DOI:10.1021/jm020160g
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 90 percent / Et3N; DMAP / CH2Cl2 / 12 h / 20 °C
2.1: 2M aq. Na2CO3; tetrakis(triphenylphosphine)palladium / ethanol; toluene / 1.25 h / Heating
3.1: Ph3P; DEAD / tetrahydrofuran
4.1: tBuLi / tetrahydrofuran; pentane / -78 °C
5.1: NaH / dimethylformamide / 0 °C
5.2: dimethylformamide
With
dmap; tetrakis(triphenylphosphine) palladium(0); tert.-butyl lithium; sodium hydride; sodium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; pentane;
2.1: Suzuki coupling / 3.1: Mitsunobu reaction;
DOI:10.1021/jm020160g
