2-chloro-N-(1-(4-chlorophenyl)-2-methylpropan-2-yl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(1-(4-chlorophenyl)-2-methylpropan-2-yl)acetamide
• CAS No.: 26094-21-3
• Molecular Formula: C₁₂H₁₅Cl₂NO
• Molecular Weight: 260.163
• Mol file: 26094-21-3.mol

Synonyms:2-chloro-N-(1-(4-chlorophenyl)-2-methylpropan-2-yl)acetamide

Chemical Property of 2-chloro-N-(1-(4-chlorophenyl)-2-methylpropan-2-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-chloro-N-(1-(4-chlorophenyl)-2-methylpropan-2-yl)acetamide

There total 3 articles about 2-chloro-N-(1-(4-chlorophenyl)-2-methylpropan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-chlorophenyl)-2-methyl-2-propanol (5468-97-3) + chloroacetonitrile (107-14-2) → 2-chloro-N-(1-(4-chlorophenyl)-2-methylpropan-2-yl)acetamide (26094-21-3)

Guidance literature:

1-(4-chlorophenyl)-2-methyl-2-propanol; chloroacetonitrile; With sulfuric acid; acetic acid; at 0 - 10 ℃;

With water; potassium carbonate; pH=> 8; Cooling with ice;

Reference yield:

(4-chloro-phenyl)-acetic acid methyl ester (52449-43-1) → 2-chloro-N-(1-(4-chlorophenyl)-2-methylpropan-2-yl)acetamide (26094-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: sulfuric acid; acetic acid / 0 - 10 °C

2.2: pH > 8 / Cooling with ice

With sulfuric acid; acetic acid; In tetrahydrofuran;

Reference yield:

→ 2-chloro-N-(1-(4-chlorophenyl)-2-methylpropan-2-yl)acetamide (26094-21-3)

Guidance literature:

entspr. Amin, /BRN= 605439/;

upstream raw materials:

1-(4-chlorophenyl)-2-methyl-2-propanol

chloroacetonitrile

(4-chloro-phenyl)-acetic acid methyl ester

Downstream raw materials:

Chlorphentermine

N-(1-(4-chlorophenyl)-2-methylpropan-2-yl)-4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-amine