Methyl-5-(benzyloxy)-3,6-diacetyl-8-methyl-3H,6H-pyrrolo<3,2-e>indol-1-carboxylat

Base Information

Chemical Name:Methyl-5-(benzyloxy)-3,6-diacetyl-8-methyl-3H,6H-pyrrolo<3,2-e>indol-1-carboxylat
CAS No.:127028-23-3
Molecular Formula:C₂₄H₂₂N₂O₅
Molecular Weight:418.449
Hs Code.:

Synonyms:Methyl-5-(benzyloxy)-3,6-diacetyl-8-methyl-3H,6H-pyrrolo<3,2-e>indol-1-carboxylat

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Chemical Property of Methyl-5-(benzyloxy)-3,6-diacetyl-8-methyl-3H,6H-pyrrolo<3,2-e>indol-1-carboxylat

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Technology Process of Methyl-5-(benzyloxy)-3,6-diacetyl-8-methyl-3H,6H-pyrrolo<3,2-e>indol-1-carboxylat

There total 10 articles about Methyl-5-(benzyloxy)-3,6-diacetyl-8-methyl-3H,6H-pyrrolo<3,2-e>indol-1-carboxylat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 127028-22-2
Methyl-3,6-diacetyl-5-(benzyloxy)-1,2-dihydro-2-hydroxy-8-methyl-3H,6H-pyrrolo<3,2-e>indol-1-carboxylat

: 127028-23-3
Methyl-5-(benzyloxy)-3,6-diacetyl-8-methyl-3H,6H-pyrrolo<3,2-e>indol-1-carboxylat

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 0.25h;
DOI:10.1002/hlca.19890720717

Reference yield: 49.0%

: 922-67-8
propynoic acid methyl ester

: 127040-11-3
N-<1-Acetyl-7-(benzyloxy)-3-methylindol-5-yl>acetohydroxamsaeure

: 127028-23-3
Methyl-5-(benzyloxy)-3,6-diacetyl-8-methyl-3H,6H-pyrrolo<3,2-e>indol-1-carboxylat

: 127028-22-2
Methyl-3,6-diacetyl-5-(benzyloxy)-1,2-dihydro-2-hydroxy-8-methyl-3H,6H-pyrrolo<3,2-e>indol-1-carboxylat

Guidance literature:: With triethylamine; In tetrahydrofuran; dimethyl sulfoxide; for 6h; Ambient temperature;
DOI:10.1002/hlca.19890720717

Reference yield:

: 127028-17-5
2-(benzyloxy)-6-bromo-4-nitro-aniline

: 127028-23-3
Methyl-5-(benzyloxy)-3,6-diacetyl-8-methyl-3H,6H-pyrrolo<3,2-e>indol-1-carboxylat

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / 4-(dimethylamino)pyridine / 48 h / 100 °C

2: 98 percent / NaOH / methanol / 2 h / Ambient temperature

3: 60 percent / Na₂CO₃ / dimethylformamide / 20 h / Heating

4: 74 percent / Bu₃N, Pd(OAc)2P(Tol₃)2 / toluene / 48 h / Heating

5: hydrogen, conc. NH₄OH, DMSO / 5 percent Pt/C / tetrahydrofuran / 1 h / 15 °C

6: NaHCO₃ / tetrahydrofuran; H₂O / 1 h / 0 °C

7: 22 percent / Et₃N / tetrahydrofuran; dimethylsulfoxide / 6 h / Ambient temperature

With dmap; ammonium hydroxide; sodium hydroxide; tributyl-amine; Pd(OAc)2P(Tol₃)2; hydrogen; sodium hydrogencarbonate; sodium carbonate; dimethyl sulfoxide; triethylamine; platinum on activated charcoal; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.19890720717