(R)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine

Base Information

• Chemical Name: (R)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine
• CAS No.: 939426-97-8
• Molecular Formula: C₂₀H₁₅ClF₄N₂
• Molecular Weight: 394.799

Synonyms:(R)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine

Chemical Property of (R)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine

Chemical Property:

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Technology Process of (R)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine

There total 1 articles about (R)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine (939039-26-6) → (S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine (939039-31-3) + (R)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine (939426-97-8)

Guidance literature:

With chiral SFC; In methanol; at 35 ℃; under 75007.5 Torr; Resolution of racemate; Inert atmosphere;

DOI:10.1021/jm300611v

Reference yield: 33.0%

(R)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine (939426-97-8) + Allyl chloroformate (2937-50-0) → (R)-allyl 1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethylcarbamate

Guidance literature:

With potassium carbonate; In 1,1-dichloroethane; at 20 ℃; for 18h;

Reference yield: 2.8%

(R)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine (939426-97-8) + benzenesulfonyl chloride (1939-99-7) → (R)-N-(1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)(phenyl)methanesulfonamide

Guidance literature:

With pyridine; In 1,1-dichloroethane; at 20 ℃; for 18h;

upstream raw materials:

1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine

Downstream raw materials:

(R)-1-(1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-3-cyclopentylurea

C₂₇H₂₆ClF₄N₃O

C₂₅H₂₂ClF₄N₃O₂

C₂₆H₂₂ClF₆N₃O

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