1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine

Base Information

Chemical Name:1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine
CAS No.:939039-26-6
Molecular Formula:C₂₀H₁₅ClF₄N₂
Molecular Weight:394.799
Hs Code.:

Synonyms:1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine

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Chemical Property of 1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine

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Technology Process of 1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine

There total 5 articles about 1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 130723-13-6
3-bromo-5-fluorobenzotrifluoride

: 89809-64-3
2-cyano-5-chloropyridine

: 6921-34-2
benzylmagnesium chloride

: 939039-26-6
1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine

Guidance literature:: 3-bromo-5-fluorobenzotrifluoride; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.25h;

2-cyano-5-chloropyridine; In tetrahydrofuran; diethyl ether; hexane; at -78 ℃; for 2h;

benzylmagnesium chloride; With chloro-trimethyl-silane; water; more than 3 stages; Product distribution / selectivity;

Reference yield: 56.0%

: 130723-13-6
3-bromo-5-fluorobenzotrifluoride

: 89809-64-3
2-cyano-5-chloropyridine

: 89523-63-7
benzylzinc chloride

: 939039-26-6
1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine

Guidance literature:: 3-bromo-5-fluorobenzotrifluoride; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.25h;

2-cyano-5-chloropyridine; In tetrahydrofuran; diethyl ether; hexane; at -78 ℃; for 2h;

benzylzinc chloride; With chloro-trimethyl-silane; water; more than 3 stages; Product distribution / selectivity;

Reference yield:

: 89809-64-3
2-cyano-5-chloropyridine

: 939039-26-6
1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.17 h / -78 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

1.2: 2 h / -78 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

1.3: -78 - 0 °C / Inert atmosphere

2.1: tetrahydrofuran; diethyl ether; hexane / 14 h / -78 - 20 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

2.2: Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; 2.1: Grignard addition;
DOI:10.1016/j.tet.2012.01.050