5-(2-Cyclopropyl-5-methyl-pyrimidin-4-yl)-A/-(2,6-difluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

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Chemical Name:5-(2-Cyclopropyl-5-methyl-pyrimidin-4-yl)-A/-(2,6-difluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide
CAS No.:1616929-92-0
Molecular Formula:C₁₉H₁₇F₂N₅O
Molecular Weight:369.374
Hs Code.:

Synonyms:5-(2-Cyclopropyl-5-methyl-pyrimidin-4-yl)-A/-(2,6-difluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

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Chemical Property of 5-(2-Cyclopropyl-5-methyl-pyrimidin-4-yl)-A/-(2,6-difluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

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Technology Process of 5-(2-Cyclopropyl-5-methyl-pyrimidin-4-yl)-A/-(2,6-difluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

There total 4 articles about 5-(2-Cyclopropyl-5-methyl-pyrimidin-4-yl)-A/-(2,6-difluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1616930-50-7
C₁₄H₁₆N₄O₂

: 5509-65-9
2,6-difluoroaniline

: 1616929-92-0
5-(2-Cyclopropyl-5-methyl-pyrimidin-4-yl)-A/-(2,6-difluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at 60 ℃; for 2h;

Reference yield:

: 17827-61-1
methyl ester of 1-methylpyrazole-3-carboxylic acid

: 1616929-92-0
5-(2-Cyclopropyl-5-methyl-pyrimidin-4-yl)-A/-(2,6-difluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / pentane / 0.33 h / 20 °C

1.2: 72 h / 20 °C

2.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dipotassium hydrogenphosphate / toluene; water / 16 h / 100 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 2 h / 60 °C

With dipotassium hydrogenphosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(tri-t-butylphosphine)palladium⁽⁰⁾; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; potassium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; hexane; water; toluene; pentane; 2.1: |Suzuki Coupling / 3.1: |Suzuki Coupling;

Reference yield:

: 1616930-49-4
C₁₁H₁₁ClN₄O₂

: 1616929-92-0
5-(2-Cyclopropyl-5-methyl-pyrimidin-4-yl)-A/-(2,6-difluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dipotassium hydrogenphosphate / toluene; water / 16 h / 100 °C / Inert atmosphere

2: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 2 h / 60 °C

With dipotassium hydrogenphosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; water; toluene; 1: |Suzuki Coupling;