(2R,3S)-4-[(4S)-4-benzyl-2-oxooxazolidine-3-yl]-3-benzyloxy-2-benzyloxycarbonylamino-4-oxo-2-trifluoromethylbutyric acid ethyl ester

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Chemical Name:(2R,3S)-4-[(4S)-4-benzyl-2-oxooxazolidine-3-yl]-3-benzyloxy-2-benzyloxycarbonylamino-4-oxo-2-trifluoromethylbutyric acid ethyl ester
CAS No.:255379-08-9
Molecular Formula:C₃₂H₃₁F₃N₂O₈
Molecular Weight:628.602
Hs Code.:

Synonyms:(2R,3S)-4-[(4S)-4-benzyl-2-oxooxazolidine-3-yl]-3-benzyloxy-2-benzyloxycarbonylamino-4-oxo-2-trifluoromethylbutyric acid ethyl ester

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Chemical Property of (2R,3S)-4-[(4S)-4-benzyl-2-oxooxazolidine-3-yl]-3-benzyloxy-2-benzyloxycarbonylamino-4-oxo-2-trifluoromethylbutyric acid ethyl ester

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Technology Process of (2R,3S)-4-[(4S)-4-benzyl-2-oxooxazolidine-3-yl]-3-benzyloxy-2-benzyloxycarbonylamino-4-oxo-2-trifluoromethylbutyric acid ethyl ester

There total 3 articles about (2R,3S)-4-[(4S)-4-benzyl-2-oxooxazolidine-3-yl]-3-benzyloxy-2-benzyloxycarbonylamino-4-oxo-2-trifluoromethylbutyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 236110-81-9
(4S)-4-benzyl-3-[2-(benzyloxy)acetyl]-1,3-oxazolan-2-one

: 255379-07-8
ethyl (2E)-2-{[(benzyloxy)carbonyl]imino}-3,3,3-trifluoropropanoate

: 255379-09-0
(2S,3R)-4-[(4S)-4-benzyl-2-oxooxazolidine-3-yl]-3-benzyloxy-2-benzyloxycarbonylamino-4-oxo-2-trifluoromethylbutyric acid ethyl ester

: 255379-08-9
(2R,3S)-4-[(4S)-4-benzyl-2-oxooxazolidine-3-yl]-3-benzyloxy-2-benzyloxycarbonylamino-4-oxo-2-trifluoromethylbutyric acid ethyl ester

Guidance literature:: With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -30 - 0 ℃; for 3h;
DOI:10.1021/jo9909397

Reference yield:

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: 255379-08-9
(2R,3S)-4-[(4S)-4-benzyl-2-oxooxazolidine-3-yl]-3-benzyloxy-2-benzyloxycarbonylamino-4-oxo-2-trifluoromethylbutyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.17 h / 20 - 50 °C

2: TiCl₄; DIPEA / CH₂Cl₂ / 3 h / -30 - 0 °C

With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1: Wittig reaction / 2: Mannich-type reaction;
DOI:10.1021/jo9909397

Reference yield:

: 81357-08-6
benzyl (triphenyl-λ⁵-phosphanilidene)carbamate

: 255379-08-9
(2R,3S)-4-[(4S)-4-benzyl-2-oxooxazolidine-3-yl]-3-benzyloxy-2-benzyloxycarbonylamino-4-oxo-2-trifluoromethylbutyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.17 h / 20 - 50 °C

2: TiCl₄; DIPEA / CH₂Cl₂ / 3 h / -30 - 0 °C

With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1: Wittig reaction / 2: Mannich-type reaction;
DOI:10.1021/jo9909397