(4S)-4-benzyl-3-(2-phenylmethoxyacetyl)-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4S)-4-benzyl-3-(2-phenylmethoxyacetyl)-1,3-oxazolidin-2-one
CAS No.:236110-81-9
Molecular Formula:C19H19NO4
Molecular Weight:325.364
Hs Code.:
DSSTox Substance ID:DTXSID80451470
Nikkaji Number:J1.124.021F
Wikidata:Q82271516
Mol file:236110-81-9.mol

Synonyms:236110-81-9;(4S)-4-benzyl-3-(2-phenylmethoxyacetyl)-1,3-oxazolidin-2-one;(S)-4-Benzyl-3-(2-(benzyloxy)acetyl)oxazolidin-2-one;2-Oxazolidinone, 3-[2-(phenylmethoxy)acetyl]-4-(phenylmethyl)-, (4S)-;SCHEMBL3308447;DTXSID80451470;LIPRFZHBWBIVOM-KRWDZBQOSA-N;AKOS027447625;3-[(Benzyloxy)acetyl]-4beta-benzyloxazolidine-2-one

Suppliers and Price of (4S)-4-benzyl-3-(2-phenylmethoxyacetyl)-1,3-oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-(+)-4-Benzyl-3-benzyloxyacetyl-2-oxazolidinone
5g
$ 1190.00

TRC
(S)-(+)-4-Benzyl-3-benzyloxyacetyl-2-oxazolidinone
500mg
$ 150.00

Medical Isotopes, Inc.
(S)-(+)-4-Benzyl-3-benzyloxyacetyl-2-oxazolidinone
5 g
$ 2200.00

Total 1 raw suppliers

Chemical Property of (4S)-4-benzyl-3-(2-phenylmethoxyacetyl)-1,3-oxazolidin-2-one

Chemical Property:

Melting Point:60-63°C
Boiling Point:499.6±28.0 °C(Predicted)
PKA:-2.44±0.40(Predicted)
PSA：55.84000
Density:1.249±0.06 g/cm3(Predicted)
LogP:2.73120
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:325.13140809
Heavy Atom Count:24
Complexity:427

Purity/Quality:: (S)-(+)-4-Benzyl-3-benzyloxyacetyl-2-oxazolidinone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(N(C(=O)O1)C(=O)COCC2=CC=CC=C2)CC3=CC=CC=C3
Isomeric SMILES:C1[C@@H](N(C(=O)O1)C(=O)COCC2=CC=CC=C2)CC3=CC=CC=C3
Uses (S)-(+)-4-Benzyl-3-benzyloxyacetyl-2-oxazolidinone is an oxazolidinone used as a building block in the synthesis of epothilones.

Technology Process of (4S)-4-benzyl-3-(2-phenylmethoxyacetyl)-1,3-oxazolidin-2-one

There total 4 articles about (4S)-4-benzyl-3-(2-phenylmethoxyacetyl)-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 19810-31-2
Benzyloxyacetyl chloride

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 236110-81-9
(4S)-4-benzyl-3-[2-(benzyloxy)acetyl]-1,3-oxazolan-2-one

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1016/j.tetasy.2004.06.048

Reference yield: 90.0%

: 30379-55-6
benzyloxyacetic acid

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 236110-81-9
(4S)-4-benzyl-3-[2-(benzyloxy)acetyl]-1,3-oxazolan-2-one

Guidance literature:: benzyloxyacetic acid; With pivaloyl chloride; triethylamine; In tetrahydrofuran;

(S)-4-Benzyl-2-oxazolidinone; With triethylamine; lithium chloride;
DOI:10.1016/j.tetasy.2009.08.006

Reference yield:

: C₁₄H₁₈O₄

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 236110-81-9
(4S)-4-benzyl-3-[2-(benzyloxy)acetyl]-1,3-oxazolan-2-one

Guidance literature:: (S)-4-Benzyl-2-oxazolidinone; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h; Inert atmosphere;

C₁₄H₁₈O₄; In tetrahydrofuran; hexane; at -78 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acs.joc.6b03060