2,4-difluoro-N-[5-[4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]benzenesulfonamide

Base Information

Chemical Name:2,4-difluoro-N-[5-[4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]benzenesulfonamide
CAS No.:1254036-69-5
Molecular Formula:C₃₀H₃₁F₂N₇O₄S
Molecular Weight:623.683
Hs Code.:

Synonyms:2,4-difluoro-N-[5-[4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]benzenesulfonamide

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Chemical Property of 2,4-difluoro-N-[5-[4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]benzenesulfonamide

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Technology Process of 2,4-difluoro-N-[5-[4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]benzenesulfonamide

There total 6 articles about 2,4-difluoro-N-[5-[4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1254036-69-5
2,4-difluoro-N-[5-[4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: methanol / 2.75 h / 0 - 10 °C / Inert atmosphere; Large scale

2: ethanol; iron / 20 - 25 °C / Large scale

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

4: pyridine / 2 h / 20 °C

5: potassium phosphate; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 3 h / 120 °C / Microwave irradiation

6: sodium hydroxide / water; isopropyl alcohol / 2 h / 20 °C

With pyridine; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ethanol; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II); potassium acetate; iron; sodium hydroxide; In 1,4-dioxane; methanol; water; isopropyl alcohol;

Reference yield:

: 1254036-88-8
2,4-difluoro-N-[5-[4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]benzenesulfonamide

: 1254036-69-5
2,4-difluoro-N-[5-[4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]benzenesulfonamide

Guidance literature:: With sodium hydroxide; In water; isopropyl alcohol; at 20 ℃; for 2h;

Reference yield:

: 1083326-73-1
N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

: 1254036-69-5
2,4-difluoro-N-[5-[4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 3 h / 120 °C / Microwave irradiation

2: sodium hydroxide / water; isopropyl alcohol / 2 h / 20 °C

With potassium phosphate; chloro(di-norbonylphosphino)(2’-dimethylamino-1,1’-biphenyl-2-yl)palladium(II); sodium hydroxide; In 1,4-dioxane; water; isopropyl alcohol;