(R,E)-1,4-bis(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)but-3-en-2-ol

Base Information

Chemical Name:(R,E)-1,4-bis(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)but-3-en-2-ol
CAS No.:1174917-14-6
Molecular Formula:C₃₀H₄₈O₅Si₂
Molecular Weight:544.879
Hs Code.:

Synonyms:(R,E)-1,4-bis(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)but-3-en-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,E)-1,4-bis(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)but-3-en-2-ol

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Technology Process of (R,E)-1,4-bis(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)but-3-en-2-ol

There total 2 articles about (R,E)-1,4-bis(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)but-3-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1174917-13-5
1-(tert-butyldimethylsilyloxy)-4-iodo-2-methoxybenzene

: 1174917-10-2
(R)-2-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-1-((2R,3R)-3-(trimethylsilyl)oxiran-2-yl)ethanol

: 1174917-14-6
(R,E)-1,4-bis(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)but-3-en-2-ol

Guidance literature:: (R)-2-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-1-((2R,3R)-3-(trimethylsilyl)oxiran-2-yl)ethanol; With n-butyllithium; tri-n-butyl-tin hydride; diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 5h; Inert atmosphere;

1-(tert-butyldimethylsilyloxy)-4-iodo-2-methoxybenzene; With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenyl-arsane; lithium chloride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 11h; Inert atmosphere;
DOI:10.1021/jo900854p

Reference yield:

: 1174917-13-5
1-(tert-butyldimethylsilyloxy)-4-iodo-2-methoxybenzene

: 1174917-11-3
(R)-2-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-1-((2S,3S)-3-(trimethylsilyl)oxiran-2-yl)ethanol

: 1174917-14-6
(R,E)-1,4-bis(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)but-3-en-2-ol

Guidance literature:: (R)-2-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-1-((2S,3S)-3-(trimethylsilyl)oxiran-2-yl)ethanol; With n-butyllithium; tri-n-butyl-tin hydride; diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 5h; Inert atmosphere;

1-(tert-butyldimethylsilyloxy)-4-iodo-2-methoxybenzene; With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenyl-arsane; lithium chloride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 11h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/jo900854p