(R)-2-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-1-((2S,3S)-3-(trimethylsilyl)oxiran-2-yl)ethanol

Base Information

Chemical Name:(R)-2-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-1-((2S,3S)-3-(trimethylsilyl)oxiran-2-yl)ethanol
CAS No.:1174917-11-3
Molecular Formula:C₂₀H₃₆O₄Si₂
Molecular Weight:396.674
Hs Code.:

Synonyms:(R)-2-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-1-((2S,3S)-3-(trimethylsilyl)oxiran-2-yl)ethanol

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Chemical Property of (R)-2-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-1-((2S,3S)-3-(trimethylsilyl)oxiran-2-yl)ethanol

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Technology Process of (R)-2-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-1-((2S,3S)-3-(trimethylsilyl)oxiran-2-yl)ethanol

There total 1 articles about (R)-2-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-1-((2S,3S)-3-(trimethylsilyl)oxiran-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: C₂₂H₃₇ClO₅Si₂

: 1174917-11-3
(R)-2-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-1-((2S,3S)-3-(trimethylsilyl)oxiran-2-yl)ethanol

Guidance literature:: C₂₂H₃₇ClO₅Si₂; With propylamine; In methanol; at 0 ℃; for 1.5h;

With ammonium chloride; In methanol;
DOI:10.1021/jo900854p

Reference yield:

: 1174917-13-5
1-(tert-butyldimethylsilyloxy)-4-iodo-2-methoxybenzene

: 1174917-11-3
(R)-2-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-1-((2S,3S)-3-(trimethylsilyl)oxiran-2-yl)ethanol

: 1174917-14-6
(R,E)-1,4-bis(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)but-3-en-2-ol

Guidance literature:: (R)-2-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-1-((2S,3S)-3-(trimethylsilyl)oxiran-2-yl)ethanol; With n-butyllithium; tri-n-butyl-tin hydride; diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 5h; Inert atmosphere;

1-(tert-butyldimethylsilyloxy)-4-iodo-2-methoxybenzene; With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenyl-arsane; lithium chloride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 11h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/jo900854p