Technology Process of 4-benzyl-2-ethylmorpholine
There total 1 articles about 4-benzyl-2-ethylmorpholine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(benzyl(2-hydroxyethyl)amino)butan-2-ol;
With
sulfuric acid;
at 140 ℃;
for 17h;
With
sodium hydroxide;
at 0 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen / 20 % Pd(OH)2/C / ethanol / 17 h
2: caesium carbonate / copper(l) iodide; 2-(2-methyl-1-oxopropane)cyclohexanone / N,N-dimethyl-formamide / 0.33 h / 125 °C
With
hydrogen; caesium carbonate;
copper(l) iodide; 20 % Pd(OH)2/C; 2-(2-methyl-1-oxopropane)cyclohexanone;
In
ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogen / 20 % Pd(OH)2/C / ethanol / 17 h
2: caesium carbonate / copper(l) iodide; 2-(2-methyl-1-oxopropane)cyclohexanone / N,N-dimethyl-formamide / 0.33 h / 125 °C
3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 16 h / 85 °C / Inert atmosphere
4: potassium phosphate / tris-(dibenzylideneacetone)dipalladium(0); XPhos / 1,4-dioxane; water / 0.2 h / 140 °C / microwave irradiation
With
potassium phosphate; hydrogen; potassium acetate; caesium carbonate;
tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; 20 % Pd(OH)2/C; 2-(2-methyl-1-oxopropane)cyclohexanone; XPhos;
In
1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
