(2-(2-amino-3-(2-ethylmorpholino)quinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

Base Information

Chemical Name:(2-(2-amino-3-(2-ethylmorpholino)quinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone
CAS No.:1319194-42-7
Molecular Formula:C₂₇H₃₂N₄O₂
Molecular Weight:444.577
Hs Code.:

Synonyms:(2-(2-amino-3-(2-ethylmorpholino)quinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

Suppliers and Price of (2-(2-amino-3-(2-ethylmorpholino)quinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2-(2-amino-3-(2-ethylmorpholino)quinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2-(2-amino-3-(2-ethylmorpholino)quinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

There total 10 articles about (2-(2-amino-3-(2-ethylmorpholino)quinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₄₀N₄O₃

: 1319194-42-7
(2-(2-amino-3-(2-ethylmorpholino)quinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

Guidance literature:: C₃₅H₄₀N₄O₃; With trifluoroacetic acid; at 70 ℃; for 18h;

With ammonia; In methanol; dichloromethane;

Reference yield:

: 53663-39-1
3-methyl-2-bromobenzoic acid

: 1319194-42-7
(2-(2-amino-3-(2-ethylmorpholino)quinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 14 h / 20 °C

1.2: 8 h

2.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 0.2 h / 140 °C / microwave irradiation

3.1: trifluoroacetic acid / 18 h / 70 °C

With potassium phosphate; 1,1'-carbonyldiimidazole; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 52769-10-5,1313176-45-2
2-ethylmorpholine

: 1319194-42-7
(2-(2-amino-3-(2-ethylmorpholino)quinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / copper(l) iodide; 2-(2-methyl-1-oxopropane)cyclohexanone / N,N-dimethyl-formamide / 0.33 h / 125 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 85 °C / Inert atmosphere

3: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 0.2 h / 140 °C / microwave irradiation

4: trifluoroacetic acid / 18 h / 70 °C

With potassium phosphate; potassium acetate; caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 2-(2-methyl-1-oxopropane)cyclohexanone; XPhos; In 1,4-dioxane; water; N,N-dimethyl-formamide;